2013 Fiscal Year Final Research Report
Development of new comprehensive heart failure treatment that takes into account the underlying disease and the stage of the heart failure
| Project/Area Number |
23591093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ASANUMA HIROSHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20416217)
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| Co-Investigator(Kenkyū-buntansha) |
ASAKURA Masanori 独立行政法人国立循環器病研究センター, 臨床研究企画室, 室長 (80443505)
KITAKAZE Masafumi 独立行政法人国立循環器病研究センター, 臨床研究部, 部長 (20294069)
HIRAIDE Atsushi 近畿大学, 医学部, 教授 (20199037)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 心不全 / トランスレーショナルリサーチ / 循環器内科学 / 分子心臓病態学 |
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| Research Abstract |
We examined whether AMPK activation can modulate cardiac remodeling and inhibit the progression of heart failure in the canine myocardial infarction model and pacing induced decompensated heart failure, which is considered to be similar to human dilated cardiomyopathy and can be superimposed on translational study for human heart failure. Neither blood pressure nor heart rate differed between the groups with and without AICAR (AMPK activator) at 6 weeks after the onset of myocardial infarction or pacing-induced heart failure. Left ventricular ejection fraction increased, and mean pulmonary arterial pressure and pulmonary capillary wedge pressure decreased in the AICAR treated group compared with the untreated group. These effects were observed in both models, even after the onset of heart failure. Thus, we conclude that AMPK activation is an important novel therapeutic target in chronic heart failure.
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Research Products
(39 results)
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[Journal Article] Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2014
Author(s)
Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y, Takashima S
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 111(1)
Pages: 273-278
Peer Reviewed
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[Journal Article] Dipeptidyl -Peptidase IV Inhibition Improves Pathophysiology of Heart Failure and Increases Survival Rate in Pressure -Overloaded Mice2013
Author(s)
Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 304(10)
Pages: H1361-H1369
Peer Reviewed
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[Journal Article] Liposomal Amiodarone Augments Anti-arrhythmic Effects and Reduces Hemodynamic Adverse Effects in an Ischemia/Reperfusion Rat Model2013
Author(s)
Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T
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Journal Title
Cardiovasc Drugs Ther.
Volume: 27(2)
Pages: 125-132
Peer Reviewed
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[Journal Article] Serum Blood Urea Nitrogen and Plasma Brain Natriuretic Peptide and Low Diastolic Blood Pressure Predict Cardiovascular Morbidity and Mortality Following Discharge in Acute Decompensated Heart Failure Patients2012
Author(s)
Chen CY, Yoshida A, Asakura M, Hasegawa T, Takahama H, Amaki M, Funada A, Asanuma H, Yokoyama H, Kim J, Kanzaki H, Kitakaze M
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Journal Title
Circ J.
Volume: 76(10)
Pages: 2372-2379
Peer Reviewed
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[Journal Article] H(2) Mediates Cardioprotection Via Involvements of K(ATP) Channels and Permeability Transition Pores of Mitochondria in Dogs2012
Author(s)
Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M
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Journal Title
Cardiovasc Drugs Ther.
Volume: 26(3)
Pages: 217-226
Peer Reviewed
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[Journal Article] Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan : the importance of the plasma adiponectin levels2012
Author(s)
Chen CY, Asakura M, Asanuma H, Hasegawa T, Tanaka J, Toh N, Min KD, Kanzaki H, Takahama H, Amaki M, Itoh Y, Ichien G, Okumoto Y, Funahashi T, Kim J, Kitakaze M
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Journal Title
Hypertens Res.
Volume: 35(8)
Pages: 843-848
Peer Reviewed
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[Journal Article] Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model2012
Author(s)
Sohma R, Inoue T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Arikawa T, Hikichi Y, Sanada S, Asanuma H, Kitakaze M, Node K
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Journal Title
J Cardiol.
Volume: 59(1)
Pages: 91-96
Peer Reviewed
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[Presentation] The E3 Ligase Asb2 Regulates Cardiac Development Through Targeting Smad9 for Proteasomal Degradation
Author(s)
Min KD, Asakura M, Ito S, Shirai M, Nakano A, Tsukamoto O, Inoue H, Yamazaki S, Asanuma H, Takashima S, Minamino T, Mochizuki N, Schneider M, Kitakaze M
Organizer
第78回日本循環器学会学術集会2014
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[Presentation] Exploratory Reserch on Potential Diagnostic as Well as Therapeutic Targets for Heart Failure Using Omics Data Analysis
Author(s)
Asakura M, Asanuma H, Ito S, Min KD, Seguchi O, Takahashi A, Nishigori M, Shindoh K, Imazu M, Nakatani T, Tomonaga T, Minamino N, Kitakaze M
Organizer
第78回日本循環器学会学術集会2014
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[Presentation] Serum Fibroblast Growth Factor 23 as a Surrogate Marker in Patients with Heart Failure
Author(s)
高濱博幸,今津美樹,浅沼博司,舟田晃,菅野康夫,大原貴裕,長谷川拓也,朝倉正紀,神崎秀明,安斉俊久,北風政史
Organizer
第61回日本心臓病学会学術集会2013
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[Presentation] BNPは冠動脈疾患発症リスクの代用マーカーとなりうるか
Author(s)
長谷川拓也,朝倉正紀,江口和男,浅沼博司,天木誠,高濱博幸,舟田晃,菅野康夫,大原貴裕,神崎秀明,橋村一彦,友池仁遙暢,金智隆,安斉俊久,北風政史
Organizer
第61回日本心臓病学会学術集会2013
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