2013 Fiscal Year Final Research Report
Angiogenic mechanism spatio-temporally controlled by Id-Notch signal crosstalk and their therapeutic application
| Project/Area Number |
23591099
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
NISHIYAMA Koichi 東京大学, 医学(系)研究科(研究院), 助教 (80398221)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 発生・分化 / 血管新生 / ライブイメージング / 転写因子 / 多細胞運動 / モデル化 |
|---|
| Research Abstract |
This study aimed to examine whether or not or how a signal crosstalk between HLH transcriptional factor Id and Notch contributes to the spatio-temporal control of endothelial cell behaviors during angiogenesis. A 4D analysis using an in vitro angiogenesis model suggested that the crosstalk possibly related to the dynamic regulation of moving speed and direction in individual endothelial cells. However, "cell sorting" phenomenon did not seem to explain the regulatory mechanism. Furthermore, we constructed a mathematical model for endothelial cell dynamics driving VEGF-induced vessel elongation, which enables us to further dissect the mechanisms systemically.
|
