The role of visceral adipose tissue CD8+ T cells in obese murine asthma model

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591120
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kochi University
• Principal Investigator: OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
• Research Collaborator: KOMIYAMA Shuzo 高知大学, 医学部, 技術補佐員
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 喘息 / CD8陽性T細胞 / 肥満 / 好酸球性気道炎症 / 気道過敏性

Outline of Final Research Achievements

Obesity is associated with poorer control of asthma. CD8+ T cells contribute to adipose tissue inflammation. Effector CD8+ T cells are associated with asthma pathogenesis. We investigated whether visceral adipose tissue CD8+ T cells can enhance asthma phenotype in murine asthma model. Obese murine asthma model showed enhanced asthma phenotype compared with non-obese asthma model. Antigen inhalational challenge after adoptive transfer of mononuclear cells from visceral adipose tissue of allergen-sensitized obese mice failed to develop or enhance asthma phenotype in non-sensitized or secondary allergen-challenged non-obese mice. Adoptive transfer of visceral adipose tissue CD8+ T cells from obese mice suppressed asthma phenotype in allergen-sensitized and -challenged non-obese mice. These data suggested that visceral adipose tissue CD8+ T cells from obese mice might suppress the development of asthma phenotype.

Free Research Field

医学、呼吸器内科学