2013 Fiscal Year Final Research Report
Targeted therapy for cancer stem-like cells of non-small cell lung cancers with inhibition of the cJun transcription factor
| Project/Area Number |
23591132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
KINOSHITA Ichiro 北海道大学, 医学(系)研究科(研究院), 准教授 (40343008)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Yasushi 北海道大学, 大学病院, 助教 (10374513)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺癌 / 癌幹細胞 / ｃJun / EZH2 |
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| Research Abstract |
Sphere forming capacity under serum-free culture, indicative of cancer stem cells, were decreased by cJun inhibition in non-small lung cancer (NSCLC) cells, while sphere forming cells did not show enhanced tumorigenicity in SCID mice.
Meanwhile, an inhibitor of histone methyltransferase EZH2 involved in stem cell maintenance via epigenetic regulation suppressed growth of NSCLC cells. An inhibitor of histone deacetylase (HDAC), another epigenetic regulator, showed a synergistic growth suppressive effect with the EZH2 inhibitor. Combined epigenetic therapy with an EZH2 inhibitor and an HDAC inhibitor may represent an effective approach for NSCLCs.
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