2013 Fiscal Year Final Research Report
Exploratory study for identifying EMT-associated genes as novel therapeutics for lung cancer
| Project/Area Number |
23591145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MITSUO Sato 名古屋大学, 医学部附属病院, 講師 (70467281)
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| Co-Investigator(Kenkyū-buntansha) |
MASASHI Kondo 名古屋大学, 大学院医学系研究科, 准教授 (00378077)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺癌 / マイクロRNA / 上皮間葉細胞転換 |
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| Research Abstract |
We evaluated the potential of miR-221 and miR222 as novel therapeutics for lung cancer. These microRNAs are shown to induce epithelial to mesenchymal transition (EMT) in normal mammary epithelial cells. Upon introduction of miR-221 or miR222, immortalized normal human bronchial epithelial cells underwent morphological changes, suggestive of EMT, in association with expression changes in EMT-associated genes. miR-221 and miR222 promoted growth in several lung cancer cell lines but suppressed in other cell lines. Cell cycle and apoptosis analyses revealed that growth suppressive effects by miR-221 and miR-221 occur through S-phase arrest and/or apoptosis. These data suggested the potential of miR-221 and miR222 as novel therapeutics for lung cancer.
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[Journal Article] TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival2012
Author(s)
Yoshida K, Sato M, Hase T, Elshazley M, Yamashita R, Usami N, Taniguchi T, Yokoi K, Nakamura S, Kondo M, Girard L, Minna JD, et al
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells2012
Author(s)
Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, et al
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Journal Title
Ann Surg Oncol
Volume: 19 Suppl 3
Pages: S634-45
DOI
Peer Reviewed
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[Journal Article] The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma2012
Author(s)
Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, et al
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Journal Title
Int J Cancer
Volume: 131
Pages: 2820-31
DOI
Peer Reviewed
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[Journal Article] Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells2011
Author(s)
Hase T, Sato M, Yoshida K, Girard L, Takeyama Y, Horio M, Elshazley M, Oguri T, Sekido Y, Shames DS, Gazdar AF, Minna JD, et al
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Journal Title
Cancer Sci
Volume: 102
Pages: 1493-500
DOI
Peer Reviewed
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[Presentation] THE COMBINATION OF FIVE CHANGES (TELOMERASE, P16/RB BYPASS, P53 KNOCKDOWN, KRASV12, C-MYC) TOGETHERWITH SERUM-INDUCED EPITHELIAL MESENCHYMAL TRANSITION PROGRESSES NORMAL HUMAN BRONCHIAL EPITHELIAL CELLS TO FULL MALIGNANCY2012
Author(s)
Mitsuo Sato, Jill E. Larsen, Woochang Lee, David Shames, Ignacio I. Wistuba, Adi F. Gazdar3, Jerry W. Shay, John D. Minna, Masashi Kondo, Yoshinori Hasegawa
Organizer
第5回アジア太平洋肺癌会議
Place of Presentation
Hilton Fukuoka Sea Hawkホテル、福岡市
Year and Date
2012-11-28
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[Presentation] Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells2011
Author(s)
Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y
Organizer
第14回世界肺癌学会
Place of Presentation
オランダ、アムステルダム
Year and Date
2011-07-04
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