2013 Fiscal Year Final Research Report
Challenge to search for lung progenitor cells and to develop alveolar type II cells from human iPS cells
| Project/Area Number |
23591146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
ITO Isao 京都大学, 医学(系)研究科(研究院), 助教 (40447975)
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| Co-Investigator(Kenkyū-buntansha) |
OSAFUNE Kenji (80502947)
NIIMI Akio (30252513)
MISHIMA Michiaki (60190625)
MURO Shigeo (60344454)
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| Project Period (FY) |
2011 – 2013
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| Keywords | iPS細胞 / 肺胞上皮細胞 / 組織幹細胞 / サーファクタント / レポーター細胞 / SPC / NKX2.1 |
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| Research Abstract |
In this study grant, we have established original methods to develop iPS cells into alveolar cells. The induced population expressed marker proteins such as surfactant protein-C, which are required for alveolar type II cells. In the process of developing induction methods, we have identified a surface marker for NKX2.1 positive cells. The marker enables us to isolate these cells and cells positive for this marker developed into a range of airway and alveolar epithelial cells. Our findings would contribute much for further research on inducing alveolar cell population from undiffereniated cells.
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Research Products
(18 results)
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[Journal Article] Prevalence and clinical relevance of allergic rhinitis in patients with classic asthma and cough variant asthma2014
Author(s)
Tajiri T, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Mishima M
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Journal Title
Respiration
Volume: 87
Pages: 211-8
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[Journal Article] Association of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma2013
Author(s)
Tajiri T, Matsumoto H, Niimi A, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Petrova G, Mishima M
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Journal Title
PLoS One
Volume: 8
Pages: e65284
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[Journal Article] Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation2013
Author(s)
Nagasaki T, Matsumoto H, Nakaji H, Niimi A, Ito I, Oguma T, Muro S, Inoue H, Iwata T, Tajiri T, Kanemitsu Y, Mishima M
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Journal Title
Clin Exp Allergy
Volume: 43
Pages: 608-15
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[Journal Article] Interferon regulatory factor 5 polymorphisms in sarcoidosis2013
Author(s)
Tanizawa K, Handa T, Nagai S, Sato H, Yamada R, Ito I, Kubo T, Ito Y, Watanabe K, Aihara K, Ikezoe K, Mishima M, Izumi T
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Journal Title
Mod Rheumatol
Volume: 23
Pages: 1158-65
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[Journal Article] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma2013
Author(s)
Nakaji H, Petrova G, Matsumoto H, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Mishima M
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 198-203
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[Journal Article] Sputum YKL-40 Levels and Pathophysiology of Asthma and Chronic Obstructive Pulmonary Disease2012
Author(s)
Otsuka K, Matsumoto H, Niimi A, Muro S, Ito I, Takeda T, Terada K, Yamaguchi M, Matsuoka H, Jinnai M, Oguma T, Nakaji H, Inoue H, Tajiri T, Iwata T, Chin K, Mishima M
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Journal Title
Respiration
Volume: 83
Pages: 507-19
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[Journal Article] Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration : comparison with imipenem/cilastatin2010
Author(s)
Ito I, Kadowaki S, Tanabe N, Haruna A, Kase M, Yasutomo Y, Tsukino M, Nakai A, Matsumoto H, Niimi A, Chin K, Ichiyama S, Mishima M
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Journal Title
Pulm Pharmacol Ther
Volume: 23
Pages: 403-10
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