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2013 Fiscal Year Final Research Report

Identification of microRNAs involved in the development of diabetic nephropathy

Research Project

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Project/Area Number 23591177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionAkita University

Principal Investigator

FUJITA HIROKI  秋田大学, 医学部, 講師 (30333933)

Co-Investigator(Kenkyū-buntansha) YAMADA Yuichiro  秋田大学, 大学院医学系研究科, 教授 (60283610)
Project Period (FY) 2011 – 2013
Keywords糖尿病性腎症 / マイクロRNA
Research Abstract

MicroRNAs (miRs) are a family of non-coding RNAs and inhibit target gene expression by causing messenger RNA degradation or by blocking protein translation. We analysed the specific expression of miRs by microarray and real-time RT-PCR using RNA extracted from whole kidneys and isolated glomeruli in two Akita diabetic mouse models which have different susceptibility to diabetic nephropathy, nephropathy-resistant C57BL/6-Akita and nephropathy-prone KK/Ta-Akita. Several miRs whose expression levels are different between C57BL/6-Akita and KK/Ta-Akita were identified in both whole kidney and glomerulus. These results indicate that the identified miRs may play an important role in the development and progression of diabetic nephropathy.

  • Research Products

    (2 results)

All 2011 Other

All Presentation (1 results) Remarks (1 results)

  • [Presentation] マイクロアレイ解析による糖尿病性腎症感受性マイクロRNAの同定2011

    • Author(s)
      藤田浩樹、森井宰、藤田麻貴、高嶋悟、小川和孝、三ケ田敦史、菅沼由美、清水尚子、清水辰徳、佐藤雄大、細葉美穂子、月山克史、成田琢磨、山田祐一郎
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp

URL: 

Published: 2015-07-16  

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