A search of factors determining bone quality in patients with chronic kidney disease

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: KAZAMA Junichiro 新潟大学, 医歯学総合病院, 准教授 (10345499)
• Project Period (FY): 2011 – 2013
• Keywords: 尿毒物質 / 骨粗鬆症 / 慢性腎臓病 / 分光分析 / 臨床研究 / 弾性力学特性

Research Abstract

We proved the common view that a bone fragility increases in patients with chronic kidney disease by a modern clinical study method. In vivo experimental studies revealed that the contribution of abnormal systemic mineral metabolism to the bone fragility was quite limited while uremic toxins directly and reversibly modified bone material properties that lead a deterioration of bone elastic mechanical properties in uremic condition.
From these findings, we proposed a new disease concept of "uremic osteoporosis", which is clearly distinct from CKD-MBD. The concept of direct modification of bone material properties by uremic toxins would not only help improving the clinical practice pattern on bone in patients with chronic kidney disease, but also provide a possible new key to elucidate the pathophysiology of senile osteoporosis.

Research Products

• [Journal Article] Regional variation in hip fracture incidence among Japanese hemodialysis patients (2014)
  • Author(s): Wakasugi M, Kazama JJ, Wada A, Taniguchi M, Tsubakihara Y, Iseki K, Narita I
  • Journal Title: Ther Apher Dial Volume: 18 Pages: 162-166
  • Peer Reviewed
• [Journal Article] Uremic osteoporosis (2013)
  • Author(s): Kazama JJ, Iwasaki Y, Fukagawa M
  • Journal Title: Kidney Int Suppl Volume: 3 Pages: 446-450
  • Peer Reviewed
• [Journal Article] Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease (2013)
  • Author(s): Iwasaki Y, Kazama JJ, Yamato H, Shimoda H, Fukagawa M
  • Journal Title: Bone Volume: 57 Pages: 477-483
  • Peer Reviewed
• [Journal Article] Increased risk of hip fracture among Japanese hemodialysis patients (2013)
  • Author(s): Wakasugi M, Kazama JJ, Taniguchi M, Wada A, Iseki K, Tsubakihara Y, Narita I
  • Journal Title: J Bone Miner Metab Volume: 31 Pages: 315-322
  • Peer Reviewed
• [Journal Article] A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan
  • Author(s): Maruyama Y, Taniguchi M, Kazama JJ, Yokoyama K, Hosoya T, Yokoo T, Shigematsu T, Iseki K, Tsubakihara Y
  • Journal Title: Nephrol Dial Transplant Volume: (in press)
  • Peer Reviewed
• [Presentation] Altered material properties are responsible for bone fragility in rats with chronic kidney disease (2013)
  • Author(s): Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
  • Organizer: The 46th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2013-11-08
• [Presentation] 腎機能低下における骨弾性率と骨密度との関係 (2013)
  • Author(s): 岩崎香子、桑原恵美子、菅野三喜男、風間順一郎
  • Organizer: 第58回日本透析医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2013-06-22
• [Presentation] 慢性血液透析患者における血中ALP値と生命予後の検討 (2013)
  • Author(s): 丸山之雄、横山啓太郎、重松隆、谷口正智、風間順一郎、細谷龍男
  • Organizer: 第58回日本透析医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2013-06-22
• [Presentation] 尿毒症性骨粗鬆症 (2013)
  • Author(s): 風間順一郎
  • Organizer: 第58回日本透析医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2013-06-21
• [Presentation] Three-dimensional Morphological Analyses Revealed that Bone Volume Indicates Trabecular Length and Branching in CKD-MBD (2013)
  • Author(s): Kazama JJ, Matsuo K, Yamamoto S, Kawamura K, Wakasugi M, Narita I
  • Organizer: The 2nd Joint Meeting of International Bone and Mineral Society and the Japanese Society of Bone and Mineral Research
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2013-06-01
• [Presentation] Accumulated Uremic Toxin Deteriorates Bone Material Properties in Rats with Chronic Kidney Disease (2013)
  • Author(s): Iwasaki Y, Kazama JJ, Matsuzaki A, Nakano T, Yamato H, Fukagawa M
  • Organizer: The 2nd Joint Meeting of International Bone and Mineral Society and the Japanese Society of Bone and Mineral Research
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2013-06-01
• [Presentation] Accumulated Uremic toxins including Indoxyl Sulfate Disturbs Bone Elastic Properties in Rats with Chronic Kidney Injury (2012)
  • Author(s): Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
  • Organizer: The 45th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2012-11-10
• [Presentation] A Higher Serum Alkaline Phosphatase Is Associated with Increased Mortality among Patients Receiving Hemodialysis in Japan (2012)
  • Author(s): Maruyama Y, Yokoyama K, Shigematsu T, Taniguchi M, Kazama JJ, Hosoya T
  • Organizer: The 45th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2012-11-09
• [Presentation] 慢性腎臓病と骨折 (2012)
  • Author(s): 風間順一郎
  • Organizer: 第14回日本骨粗鬆症学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2012-09-30
• [Presentation] 慢性腎臓病における易骨折性には骨質因子の変化が関与する (2012)
  • Author(s): 岩崎香子、松垣あいら、中野貴由、風間順一郎、深川雅史、大和英之
  • Organizer: 第14回日本骨粗鬆症学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2012-09-29
• [Presentation] 一般住民の大腿骨頸部骨折発症率で認められる地域差は血液透析患者でも認められる (2012)
  • Author(s): 若杉三奈子、風間順一郎、谷口正智、和田篤志、井関邦敏、椿原美治、成田一衛
  • Organizer: 第14回日本骨粗鬆症学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2012-09-29
• [Presentation] Kidney Dysfunction Exacerbate Bone Strength through Changing Bone Material Composition (2012)
  • Author(s): Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
  • Organizer: ISN Nexus Synposium 2012 Bone and Kidney
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2012-09-22
• [Presentation] Uremia is a potential risk for hip fracture independently from mineral metabolic condition (2012)
  • Author(s): Kazama JJ, Wakasugi M, Narita I
  • Organizer: The 1st Global Congress of Fragility Fracture Network
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2012-09-08
• [Presentation] (2012)
  • Author(s): 岩崎香子、風間順一郎、大和英之、深川雅史
  • Organizer: 第55回日本腎臓学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-03
• [Presentation] Uremic toxins exacerbate bone mechanical property in chronic kidney disease (2011)
  • Author(s): Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
  • Organizer: The 44th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2011-11-11
• [Presentation] Increased risk of hip fracture among hemodialysis patients masks the influence of ethnic difference (2011)
  • Author(s): Wakasugi M, Kazama JJ, Taniguchi M, Wada A, Iseki K, Tsubakihara Y, Narita I
  • Organizer: The 44th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2011-11-11
• [Presentation] CKD患者の骨病変ー形態学的アプローチー (2011)
  • Author(s): 風間順一郎
  • Organizer: 第29回日本骨代謝学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-30
• [Presentation] わが国の透析患者の大腿骨頸部骨折発症率は米国白人患者より低い可能性がある (2011)
  • Author(s): 若杉三奈子、風間順一郎、成田一衛
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-19