2013 Fiscal Year Final Research Report
Gliogenesis and angiogenesis: possible regenerative targets in spinal cord of a transgenic model of ALS
| Project/Area Number |
23591229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
WARITA Hitoshi 東北大学, 医学(系)研究科(研究院), 助教 (30400245)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 臨床神経分子遺伝学 / 神経再生 / 運動ニューロン / 神経変性 |
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| Research Abstract |
Amyotrophic lateral sclerosis (ALS) is an adult-onset devastating disease characterized by degeneration of motor neurons. Although neural stem/progenitor cells reside around the central canal of adult spinal cord, neurogenesis does not occur under physiological condition. Previous reports showed diverse results on neurogenesis in ALS model mice.
In this study, we examined a possible regenerative response in an ALS rat model. After onset of the disease, multiple immunohistochemistry with selective cell markers revealed a significant increase of neural progenitor cells around the central canal with prominent proliferation of glial cells throughout parenchyma. As compared with control, intrathecal infusion of an angiogenesis-modulating agent for 14 days significantly reduced gliogenesis, increased number of neuroblastic cells, and partial neuroprotection in the spinal cord of ALS rats.
Therefore, modulating angiogenesis or/and gliogenesis may be a novel regenerative target in ALS.
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[Journal Article] ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis2013
Author(s)
Tanaka H, Shimazawa M, Takata M, Kaneko H, Tsuruma K, Ikeda T, Warita H, Aoki M, Yamada M, Takahashi H, Hozumi I, Minatsu H, Inuzuka T, Hara H
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Journal Title
J Neurol
Volume: 260(7)
Pages: 1782-1797
Peer Reviewed
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