2013 Fiscal Year Final Research Report
Analysis for Detection of Immunogenic Site on Aquaporin-4 in Neuromyelitis Optica
| Project/Area Number |
23591232
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
MASAHIRO Mori 千葉大学, 医学部附属病院, 講師 (70345023)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIWASA Takaki 千葉大学, 医学研究院, 准教授 (30260251)
KUNIMATSU Toshimi 名古屋女子大学, 家政学部, 教授 (70145746)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 神経免疫疾患 / 視神経脊髄炎 / 多発性硬化症 / 抗アクアポリン４抗体 |
|---|
| Research Abstract |
We performed anlysis using arrays consisting synthesized 156 peptides using peptide library data from entire human aquaporin-4 (AQP4) 'isoform a' sequences on a cellulose membrane. These peptides were reacted with serum samples obtained from 22 individuals with neuromyelitis optic (NMO), and 8 disease/normal controls. As a result, we can detect the immunogenic site on AQP4 that is recognized by the anti-AQP4 antibody in NMO patients. A peptides derived from an extracellular loop A of AQP4 may be a central immunogenic site on AQP4 in NMO. We have presented these resutls in domestic and international conferences.
|
