Crosstalk of glia and neuron: Broad-band EEG and neuroimaging analysis for epileptic foci

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: IKEDA akio 京都大学, 医学(系)研究科(研究院), 教授 (90212761)
• Co-Investigator(Kenkyū-buntansha): 宮本 享 京都大学, 医学研究科, 教授 (70239440) ; 松本 理器 京都大学, 医学研究科, 准教授 (00378754) ; 澤本 伸克 京都大学, 医学研究科, 講師 (90397547) ; 松橋 眞生 京都大学, 脳機能総合センター, 准教授 (40456885)
• Project Period (FY): 2011 – 2013
• Keywords: 発作時DC電位 / 高周波数律動 / てんかん焦点 / グリア細胞 / 神経細胞 / 広域周波数帯域脳波

Research Abstract

Recently it has been suggested that glia could be actively involved in epileptogenicity in addition to pathological firing of neurons (Iked et al, 1997, 1999). It has been thought that ictal DC shifts could reflect sustained depolarization of neurons augmented by glial passive depolarization, but receently active and earlier role of glia for ictal DC shifts has been suggested. High frequency oscillation (HFO) could reflect neural firing activity. We clarified the features of ictal DC shifts and HFO and implicated them closely in generating epileptic seizures. Additionally, it was also suggested that DC shifts and HFO had distinct generating mechanisms. We aimed to apply the results for delineating epileptic foci in each patients and to provide our findings to neuroscience.

Research Products

• [Journal Article] A novel SCN1A mutation at a cytoplasmic loop in intractable juvenile myoclonic epilepsy without febrile seizures : a case report (2014)
  • Author(s): Jingami N, Matsumoto R, Ito H, Ishii A, Ihara Y, Hirose S, Ikeda A, Takahashi R
  • Journal Title: Epil Disord Volume: (in press)
• [Journal Article] Temporal lobe epilepsy with amygdala enlargement : a morphologic and functional study (2014)
  • Author(s): Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
  • Journal Title: J Neuroimaging Volume: 24 Pages: 54-62
  • DOI: 10.1111/j.1552-6569.2011.00694.x
• [Journal Article] Automatic reference selection for quantitative EEG interpretation : Identification of diffuse/localised activity and the active earlobe reference, iterative detection of the distribution of EEG rhythms (2014)
  • Author(s): Wang B, Wang X, Ikeda A, Nagamine T, Shibasaki H, Nakamura M
  • Journal Title: Med Eng Phys Volume: 36(1) Pages: 88-95
  • DOI: 10.1016/j.medengphy.2013.10.002
• [Journal Article] Automatic interpretation and writing a report of the adult waking electroencephalogram (2014)
  • Author(s): Shibasaki H, Nakamura M, Sugi T, Nishida S, Nagamine T, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: (in press)
  • DOI: 10.1016/j.clinph.2013.12.114
• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Mapping Volume: (in press)
  • DOI: 10.1002/hbm.22479
• [Journal Article] Evaluation of seizure foci and genes in the Lgi1L385R/+ mutant rat (2014)
  • Author(s): Fumoto N, Mashimo T, Masui A, Ishida S, Mizuguchi Y, Minamimoto S, Ikeda A, Takahashi R, Serikawa T, Yukihiro Ohno Y
  • Journal Title: Neurosci Res Volume: 80 Pages: 69-75
  • DOI: 10.1016/j.neures.2013.12.008
• [Journal Article] Persistent, very frequent subclinical seizures could impair memory even after clinical remission in smoldering limbic encephalitis (2014)
  • Author(s): Kanazawa K, Matsumoto R, Shimotake A, Kinoshita M, Otsuka A, Watanabe A, Tanaka K, Takahashi R, Ikeda A
  • Journal Title: Epil Disord Volume: (in press)
• [Journal Article] Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease (2013)
  • Author(s): Fumuro T, Matsuhashi M, Mitsueda T, Inouchi M, Hitomi T, Nakagawa T, Matsumoto R, Kawamata J, Inoue H, Mima M, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 124(7) Pages: 1398-405
  • DOI: 10.1016/j.clinph.2013.01.026
• [Journal Article] Internal structural change in the hippocampus observed on 3-tesla MRI in patients with mesial temporal lobe epilepsy (2013)
  • Author(s): Mitsueda T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H Takahashi R
  • Journal Title: Int Med Volume: 52(Epub) Pages: 877-85
• [Journal Article] Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator for laterality of seizure focus in temporal lobe epilepsy : comparison among double inversion recovery, FLAIR and T2W Imaging (2013)
  • Author(s): Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Journal Title: Eur Radiol Volume: 23 Pages: 3-11
  • DOI: 10.1007/s00330-012-2565-4
• [Journal Article] Prolonged ictal monoparesis with parietal PLEDs (2013)
  • Author(s): Murahara T, Kinoshita M, Matsui M, Yamashita K, Ikeda A, Takahashi R
  • Journal Title: Epi Disord Volume: 15(2) Pages: 197-202
  • DOI: 10.1684/epd.2013.0567
• [Journal Article] Pre-SMA actively engages in conflict processing in human : a combined study of epicortical ERPs and direct cortical stimulation (2013)
  • Author(s): Usami K, Matsumoto R, Kunieda T, Shimotake A, Matsuhashi M, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Neuropsychologia Volume: 51 Pages: 1011-7
  • DOI: 10.1016/j.neuropsychologia.2013.02.002
• [Journal Article] Role of posterior parietal cortex in reaching movements in humans. Clinical implication for'optic ataxia' (2013)
  • Author(s): Inouchi M, Matsumoto R, Taki J, Kikuchi T, Mitsueda-Ono T, Nobuhiro Mikuni N, Wheaton L, Hallett M, Fukuyama H, Shibasaki H, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 124(11) Pages: 2230-41
  • DOI: 10.1016/j.clinph.2013.05.011
• [Journal Article] Higher degree of clinical anticipation in maternal transmission in benign adult familial myoclonus epilepsy in Japan (2013)
  • Author(s): Hitomi T, Kobayashi K, Jingami N, Nakagawa T Imamura H, Matsumoto R, Kondo T, Chin K, Takahashi R, Ikeda A
  • Journal Title: Epi Disord Volume: 15(4) Pages: 428-32
  • DOI: 10.1684/epd.2013.0608
• [Journal Article] Long-term seizure outcome following resective surgery for epilepsy : to be or not to be completely cured? (2013)
  • Author(s): Kunieda T, Mikuni N, Shibata S, Inano R, Yamao Y, Kikuchi T, Matsumoto R, Takahashi J, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Neurol Med Chir Volume: 53(11)(Epub 2013 Oct 21) Pages: 805-13
• [Journal Article] Evaluation of Focus Laterality in Temporal Lobe Epilepsy : A Quantitative Study Comparing Double Inversion-Recovery MR Imaging at 3T with FDG-PET (2013)
  • Author(s): Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi T, Togashi K
  • Journal Title: Epilepsia Volume: 54(12) Pages: 2174-83
  • DOI: 10.1111/epi.12396
• [Journal Article] Faciobrachial dystonic seizureで初発したくすぶり型の抗leucine-rich glioma- inactivated 1 (LGI1)抗体陽性辺縁系脳炎の1例 (2013)
  • Author(s): 中奥由里子、眞木崇州、金澤恭子、松本理器、福山秀直、高橋良輔、池田昭夫
  • Journal Title: 臨床神経学 Volume: 53 Pages: 706-711
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] 急性無菌性髄膜脳炎の経過中に局所性皮質反射性ミオクローヌスを呈し抗グルタミン酸受容体抗体が検出された2例 (2013)
  • Author(s): 戸島麻耶、人見健文、陣上直人、谷岡洸介、山門穂高、松本理器、高橋幸利、池田昭夫、髙橋良輔
  • Journal Title: 臨床神経学 Volume: (印刷中)
• [Journal Article] Clinical anticipation in Japanese families of benign adult familial myoclonus epilepsy (2012)
  • Author(s): Hitomi T, Kondo T, Kobayashi K, Matsumoto R, Takahashi R, Ikeda A
  • Journal Title: Epilepsia Volume: 53(2) Pages: e33-6
  • DOI: 10.1111/j.1528-1167.2011.03349.x
• [Journal Article] Asymmetric bilateral effect of the supplementary motor area proper in the human motor system (2012)
  • Author(s): Kikuchi T, Matsumoto R, Mikuni N, Yokoyama Y, Matsumoto A, Ikeda A, Fukuyama H, Miyamoto S, Hashimoto N
  • Journal Title: Clin Neurophysiol Volume: 123 Pages: 324-34
  • DOI: 10.1016/j.clinph.2011.06.011
• [Journal Article] Parieto-frontal network in humans studied by cortico- cortical evoked potential (2012)
  • Author(s): Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H and Lüders HO
  • Journal Title: Hum Brain Mapp Volume: 33 Pages: 2856-72
  • DOI: 10.1002/hbm.21407
• [Journal Article] Modern technology calls for a modern approach to classification of epileptic seizures and the epilepsies (2012)
  • Author(s): Lüders H, Amina S, Baumgartner C, Benbadis S, Bermeo-Ovalle A, Devereaux M, Diehl B, Edwards J, Baca-Vaca GF, Hamer H, Ikeda A, Pestana E, Rosenow F, Shahid A, Steinhoff BJ, Syed T, Tanner A, Tsuji S
  • Journal Title: Epilepsia Volume: 53(3) Pages: 405-11
  • DOI: 10.1111/j.1528-1167.2011.03376.x
• [Journal Article] A rat model for LGI1-related epilepsies (2012)
  • Author(s): Baulac S, Ishida S, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T
  • Journal Title: Hum Mol Genet Volume: 21 Pages: 3546-57
  • DOI: 10.1093/hmg/dds184
• [Journal Article] てんかん性視覚保続発作に内側側頭葉と頭頂葉の関与が示唆された1例 (2012)
  • Author(s): 當間圭一郎、田口敬子、池田昭夫、西中和人、宇高不可思、亀山正邦
  • Journal Title: 臨床神経学 Volume: 52 Pages: 651-5
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] 脳波自動判読システムにおける短時間脳波の自動検出と特徴抽出-優位律動と徐波の検出 (2012)
  • Author(s): 西田茂人、杉剛直、松橋眞生、池田昭夫、長峯隆、柴崎浩、中村政俊
  • Journal Title: 臨床神経生理学 Volume: 41 Pages: 127-33
• [Journal Article] Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy (2011)
  • Author(s): Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, Matsumoto R, Terada K, Kanda M, Matsuhashi M, Nagamine T, Shibasaki H, Takahashi R
  • Journal Title: Mov Disord Volume: 26 Pages: 1509-14
  • DOI: 10.1002/mds.23653
• [Journal Article] Left anterior temporal cortex actively engages in speech perception : a direct cortical stimulation study (2011)
  • Author(s): Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Neuropsychologia Volume: 49 Pages: 1350-1354
  • DOI: 10.1016/j.neuropsychologia.2011.01.023
• [Journal Article] Ictal Wideband ECoG : direct comparison between ictal slow shifts and high frequency oscillations (2011)
  • Author(s): Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 122 Pages: 1500-4
  • DOI: 10.1016/j.clinph.2010.12.060
• [Journal Article] Amygdalar enlargement in patients with temporal lobe epilepsy (2011)
  • Author(s): Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 82 Pages: 652-7
  • DOI: 10.1136/jnnp.2010.206342
• [Journal Article] Decreased cortical excitability in Unverricht-Lundborg disease in the long-term follow-up : a consecutive SEP study (2011)
  • Author(s): Kobayashi K, Matsumoto R, Kondo T, Kawamata J, Hitomi T, Inouchi M, Matsuhashi M, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 122 Pages: 1617-21
  • DOI: 10.1016/j.clinph.2011.01.039
• [Journal Article] Transient myoclonic state with asterixis : primary motor cortex hyperexcitability is correlated with myoclonus (2011)
  • Author(s): Hitomi T, Ikeda A, Inouchi M, Imamura H, Nakagawa T, Fumuro T, Matsumoto R, Takahashi R
  • Journal Title: Int Med Volume: 50(20)(Epub 2011 Oct 15) Pages: 2303-9
• [Journal Article] An automatic spike detection system based on elimination of false positives using the large-area context in the scalp EEG (2011)
  • Author(s): Ji Z, Sugi T, Goto S, Wang X, Ikeda A, Nagamine T, Shibasaki H, Nakamura M
  • Journal Title: IEEE Trans Biomed Eng Volume: 58(9) Pages: 2478-88
  • DOI: 10.1109/TBME.2011.2157917
• [Journal Article] Automatic interpretation of hyperventilation-induced electroencephalogram constructed in the way of qualified electroencephalographer's visual inspection (2011)
  • Author(s): Zhang X, Wang X, Sugi T, Ikeda A, Nagamine T, Shibasaki H, Nakamura M
  • Journal Title: Med Biol Eng Comput Volume: 49(2) Pages: 171-80
  • DOI: 10.1007/s11517-010-0688-9
• [Journal Article] Rippling is not always electrically silent in rippling muscle disease (2011)
  • Author(s): Maki T, Matsumoto R, Kohara N, Kondo T, Son I, Mezaki T, Nishino I, Ikeda A, Takahashi R
  • Journal Title: Muscle & Nerve Volume: 43(4) Pages: 601-5
  • DOI: 10.1002/mus.21947
• [Journal Article] けいれん様不随意運動の発現に基底核の関与が示唆されたconvulsive syncopeの1例 (2011)
  • Author(s): 村原貴史、高屋成利、山口大介、田中智洋、福山秀直、池田昭夫、高橋良輔
  • Journal Title: 臨床神経学 Volume: 51 Pages: 338-344
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Presentation] Invasive EEG Recording to Define Epileptic Zone. Symposium : EEG in Diagnosis of Seizures and Epilepsy (2013)
  • Author(s): Ikeda A
  • Organizer: 5th Asian and Oceanian Congress of Clinical Neurophysiology
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 20130828-31
  • Invited
• [Presentation] Controversy session : Localization : electrophysiology vs. metabolism. Seizures : EEG and MEG are the best. Controversy session : Localization (2013)
  • Author(s): Ikeda A
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal Canada
  • Year and Date: 20130623-27
  • Invited
• [Presentation] Teaching session, What's new in diagnostics. The new EEG era. Recording and interpreting, DC shifts and ultra-slow activity. Controversy session : Localization (2013)
  • Author(s): Ikeda A
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal Canada
  • Year and Date: 20130623-27
  • Invited
• [Presentation] Movement disorders and epilepsy. The relationship between myoclonus and epilepsy : New insights from, neurophysiological and genetic studies in myoclonus dystonia and familial cortical tremor (2013)
  • Author(s): Ikeda A
  • Organizer: 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20130616-20
  • Invited
• [Presentation] グリアとてんかん病態発作時DC脳波の発生機構:てんかん焦点のグリアの関与 (2013)
  • Organizer: 第47回日本てんかん学会
  • Place of Presentation: 小倉(シンポジウム1)
  • Year and Date: 2013-10-11
• [Book] 症例から学ぶ戦略的てんかん診断・治療 (2014)
  • Author(s): 池田昭夫(編)
  • Publisher: 南山堂、東京
• [Book] てんかん専門医ガイドブック、日本てんかん学会編 (2014)
  • Author(s): 池田昭夫(編集委員)
  • Total Pages: 105-109
  • Publisher: 診断と治療社、東京
• [Book] 脳波検査、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床 (2012)
  • Author(s): 松本理器、池田昭夫(宇川義一編)
  • Total Pages: 104-115
  • Publisher: 中山書店、東京
• [Book] 成人の薬物療法-総論、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床 (2012)
  • Author(s): 小林勝哉、池田昭夫(宇川義一編)
  • Total Pages: 177-187
  • Publisher: 中山書店、東京
• [Book] 高齢発症てんかん患者診療のポイント、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床 (2011)
  • Author(s): 木下真幸子、三枝隆博、池田昭夫(宇川義一編)
  • Total Pages: 80-87
  • Publisher: 中山書店、東京
• [Book] 日本てんかん学会ガイドライン作成委員会報告高齢者のてんかんの診断・手術適応ガイドライン、てんかん研究28: (2011)
  • Author(s): 池田昭夫.日本てんかん学会ガイドライン作成委員会(藤原建樹、池田昭夫、井上有史、亀山茂樹、須貝研司)
  • Total Pages: 509-514
• [Book] てんかん治療ガイドライン、高齢発症てんかんの治療
  • Author(s): 宇佐美清英、池田昭夫
  • Publisher: 日本神経治療学会(印刷中)
• [Remarks]
  • URL: http://epilepsy.med.kyoto-u.ac.jp