Posture abnormality in patients with Parkinson's and related disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591280
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Wakayama Medical University
• Principal Investigator: MURATA Kenya 和歌山県立医科大学, 医学部, 准教授 (90264853)
• Co-Investigator(Kenkyū-buntansha): MIWA Hideto 順天堂大学, 医学部, 准教授 (50231626) ; NAKANISHI Ichiro 和歌山県立医科大学, 医学部, 助教 (40364088) ; HIWATANI Yasuhiro 和歌山県立医科大学, 医学部, 助教 (40405452) ; KOUDA Ken 和歌山県立医科大学, 医学部, 非常勤講師 (20433352)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 筋病理

Outline of Final Research Achievements

Approximately 70% of the Parkinson's disease patients showed scoliosis. Fat in the erector spinae muscles were diffusely infiltrated in the half of the scoliosis patients. Paraspinal muscle atrophy, in the middle portion of the longissimus muscles, was remarkable in Parkinson's disease patients with scoliosis. The degree of fat infiltration and atrophy of the paraspinal muscles correlated with the severity of ADL disturbance in Parkinson's disease patients with scoliosis.
Various mechanisms may contribute to the development of Parkinsonian scoliosis. Dopaminergic depletion in Parkinson's disease may induce functional changes in the organization of the corticospinal and reticulospinal tracts, and dysfunction may contribute to axial rigidity. To prevent the scoliosis, treatment interventions such as an appropriate pharmacotherapy and rehabilitation at the early stage of Parkinson's disease is very important.

Free Research Field

神経内科学