Investigation of the mechanism of lifestyle-related diseases through the functional analysis of Semaphorin 3G, with the goal of developing a novel biomarker.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Chiba University
• Principal Investigator: TAKEMOTO Minoru 千葉大学, 医学(系)研究科(研究院), 准教授 (60447307)
• Co-Investigator(Kenkyū-buntansha): YOKOTE Koutaro 千葉大学, 大学院医学研究院, 教授 (20312944)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: Semaphorin3g / 心腎連関 / 糖代謝

Outline of Final Research Achievements

The purpose of this study was to investigate the mechanism of lifestyle-related diseases, such as glucose dysregulation, atherosclerosis, and kidney diseases, through the functional analysis of Sema3G, with the goal of developing a novel biomarker.
First, we found that Sema3G had a role in sympathetic nerve navigation and correct positioning to the islets of Langerhans. We also found that Sema3G not only had a role in development of atherosclerosis, but also inhibited inflammation within kidney glomeruli. Through our data, we surmise that Sema3G could be an important factor for lifestyle-related diseases through the modulation of glucose dysregulation, atherosclerosis, and kidney diseases.

Free Research Field

内科