Regeneration of pancreatic beta-cell from pancreatic SP cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591309
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kyushu University
• Principal Investigator: KATSUTA HITOSHI 九州大学, 医学(系)研究科(研究院), 講師 (50333240)
• Co-Investigator(Kenkyū-buntansha): NAGAFUCHI Seiho 九州大学, 医学(系)研究科(研究院), 教授 (00150441)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 膵ベータ細胞

Outline of Final Research Achievements

To conquer type 1 diabetes, many efforts have been made to regenerate pancreatic beta-cells from a variety of cells including the pluripotent stem cells, such as ES cells and iPS cells but we have not yet succeeded to get fully functional pancreatic beta-cells enough to clinical use. In this study, we have tried to identify substances which induce insulin-producing cells from pancreatic SP cells that are considered pancreatic stem cells.
In this study, we have succeeded to pick up several substances that induced insulin-producing cells from pancreatic SP cells. These results will give an important basis for the development of pancreatic β cell regenerative therapy using pancreatic stem cells.

Free Research Field

糖尿病学