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2013 Fiscal Year Final Research Report

Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis

Research Project

  • PDF
Project/Area Number 23591339
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionJichi Medical University

Principal Investigator

OSUGA JUN-ICHI  自治医科大学, 医学部, 准教授 (10334400)

Co-Investigator(Kenkyū-buntansha) ISHIBASHI Shun  自治医科大学, 医学部, 教授 (90212919)
YAGYU Hiroaki  自治医科大学, 医学部, 非常勤講師 (60348018)
Project Period (FY) 2011 – 2013
Keywordsマクロファージ / コレステロールエステル / 泡沫化 / 粥状動脈硬化症
Research Abstract

NCEH1 plays a principal role for cholesteryl ester hydrolase at optimal neutral pH in macrophages. Gene-knockout studies revealed that NCEH1 would have a deep relationship with foam cell formation and atherosclerotic development. In addition, it is suggested by experiments using the enzymatic inhibitor that NCEH1 might be a main enzyme in human macrophages and immunohistochemical analyses demonstrate that NCEH1 exists in the aortic area stained by anti-CD68 antibody. Furthermore oxysterols could augment the induction of apoptosis in foam cells lacking NCEH1 and advance the severity of atherosclerotic lesions. NCEH1 is a key molecule to understand the pathogenesis of atherosclerosis and lead to clinical applications including its diagnosis and treatment.

  • Research Products

    (6 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Remarks (1 results)

  • [Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

    • Author(s)
      Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S
    • Journal Title

      J Lipid Res

      Volume: 54(4)(Epub 2013 Feb 3) Pages: 1124-34

    • DOI

      10.1194/jlr.M035568

    • Peer Reviewed
  • [Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013

    • Author(s)
      Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
    • Journal Title

      J Atheroscler Thromb

      Volume: 20(5)(Epub 2013 Mar 7) Pages: 481-93

    • URL

      https://www.jstage.jst.go.jp/article/jat/20/5/20_16592/_article

    • Peer Reviewed
  • [Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death2012

    • Author(s)
      Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32(8)(Epub 2012 Jun 14) Pages: 1824-31

    • DOI

      10.1161/ATVBAHA.111.240754

    • Peer Reviewed
  • [Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011

    • Author(s)
      Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(8)(Epub 2011 May 20) Pages: 713-9

    • URL

      https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article

    • Peer Reviewed
  • [Journal Article] The role of neutral cholesterol ester hydrolysis in macrophage foam cells2011

    • Author(s)
      Sekiya M, Osuga J, Igarashi M, Okazaki H, Ishibashi S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(5)(Epub 2011 Apr 6) Pages: 359-64

    • URL

      https://www.jstage.jst.go.jp/article/jat/18/5/18_7013/_article

    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/naika/

URL: 

Published: 2015-07-16  

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