2013 Fiscal Year Final Research Report
Elucidation of the pathogenic mechanism of hyperuricemia in obesity and metabolic syndrome
| Project/Area Number |
23591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Makiko 東京薬科大学, 薬学部, 助教 (80447557)
ICHIDA Kimiyoshi 東京薬科大学, 薬学部, 教授 (80183169)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 高尿酸血症 |
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| Research Abstract |
It was studied using a high-fat diet-treated mice and obesity model of ob/ob mice to elucidate mechanism for the development of hyperuricemia in obesity and metabolic syndrome. Among the expression of urate transporters URAT1, GLUT9, ABCG2 in the kidney of these mice, urate reabsorptive transporter URAT1 was significantly increased in the amount of protein expression while the amount of mRNA expression was invariant.
In order to see the changes in plasma uric acid by high-fat diet administration, we conducted the establishment of the method of breeding maintenance of uricase knockout mice which is lost uricase activity like humans, and we also established a strain of uricase-URAT1 double knockout mice.
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[Journal Article] Common dys-functional variants in ABCG2 are a major cause of early-onset gout2013
Author(s)
Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N
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Journal Title
Sci Rep
Volume: 3
Pages: 2014
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[Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia2012
Author(s)
Ichida K, Matsuo H, Takada T, Nakayama A, Murakami K, Shimizu T, Yamanashi Y, Kasuga H, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Inoue H, Okada C, Utsumi Y, Ikebuchi Y, Ito K, Nakamura M, Shinohara Y, Hosoyamada M, Sakurai Y, Shinomiya N, Hosoya T, Suzuki H
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Journal Title
Nat Commun
Volume: 3
Pages: 764-770
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