2013 Fiscal Year Final Research Report
Regulation of macrophage foam cell formation and atherosclerotic diseases by cell adhesion signalling
| Project/Area Number |
23591341
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞接着斑分子 / Hic-5 / 動脈硬化 / 大動脈瘤 |
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| Research Abstract |
We created double-KO mice lacking both Hic-5, a cell adhesion molecule, and apoE. Angiotensin II-induced abdominal aortic aneurysm occurred to 87% of apoE-KO mice but only to 11% of double-KO mice. Similar results were obtained from mice lacking Hic-5 specifically in vascular smooth muscle cells. Atherosclerotic lesion areas in double-KO mice were suppressed to 40% of apoE-KO mice. Formation of microvilli-like structures on endothelial cell surface was suppressed in double-KO mice. Furthermore, monocyte adhesion to endothelial cells from double-KO mice was suppressed compared with apoE-KO mice. These results suggest that Hic-5 in vascular smooth muscle cells and endothelial cells plays essential roles in the development of atherosclerotic cardiovascular diseases.
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Research Products
(29 results)
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[Journal Article] Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein2014
Author(s)
Sasabe N, Keyamura Y, Obama T, Inoue N, Igarashi Y, Aiuchi T, Kato R, Yamaguchi T, Kuwata H, Iwamoto S, Miyazaki A, Hara S, Yoshikawa T, Itabe H
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Journal Title
Lipids Health Dis
Volume: 13
Pages: 48
DOI
Peer Reviewed
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[Journal Article] Identification of Hic-5 as a novel regulatory factor for integrinαIIbβ3 activation and platelet aggregation in mice2012
Author(s)
Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, Shioda S, Miyazaki A
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Journal Title
J Thromb Haemostat
Volume: 10(9)
Pages: 1867-1874
DOI
Peer Reviewed
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[Journal Article] m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its role in VE-cadherin disorganization and atherosclerosis2011
Author(s)
Miyazaki T, Taketomi Y, Takimoto M, Lei XF, Arita S, Kim-Kaneyama J, Arata S, Ohata H, Ota H, Murakami M, Miyazaki A
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Journal Title
Circulation
Volume: 124(23)
Pages: 2522-2532
DOI
Peer Reviewed
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[Presentation] m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis2012
Author(s)
Miyazaki T, Taketomo Y, Takimoto M, Lei XF, Arita S, Kim-Kaneyama JR, Arata S, Ohata H, Ota H, Murakami M, Miyazaki A
Organizer
第44回日本動脈硬化学会学術集会
Place of Presentation
福岡
Year and Date
20120719-20
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