2013 Fiscal Year Final Research Report
Regulatory mechanism for processing acute stress responses in the hypothalamus by prolacin-releasing peptide
| Project/Area Number |
23591343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOI Keiichi 東北大学, 情報科学研究科, 教授 (60232427)
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| Co-Investigator(Kenkyū-buntansha) |
FUSE Toshimitsu 東北大学, 大学院情報科学研究科, 助教 (50401039)
UCHIDA Katsuya 東北大学, 大学院情報科学研究科, 助教 (40344709)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOKAWA Hiroshi 東北福祉大学, 健康学部, 教授 (30227467)
SAKIMURA Kenji 新潟大学, 脳研究所, 教授 (40162325)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ノルアドレナリン / ストレス / 視床下部 / 副腎皮質ホルモン / 脳幹部 / 神経ペプチド / バゾプレシン / CRF |
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| Research Abstract |
Prolactin-releasing peptide (PrRP) is colocalized with noradernaline (NA) in the medulla. We examined whether PrRP and/or NA are involved in activation of neuroendocrine neurons, including corticotropin-releasing factor (CRF) neurons,in the paraventricular nucleus of the hypothalamus (PVN). It was demonstrated that PrRP-containing NA neurons are activated by stress, and that NA and PrRP work in a cooperative manner in the PVN. Using a PVN slice of the CRF-Venus konckin mouse, it was shown that NA stimulates CRF neurons via glutamatergic inputs.
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[Journal Article] Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice2013
Author(s)
Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So KH, Kawada T, Inoue N, Ikeda I, Roh SG, Itoi K, Nishimori K
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Journal Title
Endocrinology
Volume: 154
Pages: 4305-4315
Peer Reviewed
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[Presentation] 視床下部CRFニューロン蛍光可視化動物を用いた研究の展望2013
Author(s)
井樋慶一,Ashraf Hossain Talukder,小澤遼,布施俊光,佐藤隆幸,菅谷琢磨,山崎真弥,阿部学,夏目里恵,崎村健司
Organizer
第41回自律神経生理研究会
Place of Presentation
日本光電(株)本社研修センター,東京
Year and Date
2013-12-07
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[Presentation] Development of a mouse line for visualizing corticotropin-releasing factor (CRF) neurons : a study for electrophysiological characterization of CRF neurons in the hypothalamic paraventricular nucleus2013
Author(s)
Ryo Ozawa, Ashraf Hossain Talukder, Takuma Sugaya, Takayuki Sato, Yuya Yoshida, Naoya Sugimoto, Kenji Sakimura, Toshimitsu Fuse, Keiichi Itoi
Organizer
第36回内藤カンファレンス,分子からみたエネルギーバランスと摂食行動の制御
Place of Presentation
シャトレーゼガトーキングダムサッポロ,札幌
Year and Date
2013-09-10
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[Presentation] コルチコトロピン放出因子産生ニューロン蛍光可視化マウスの作出と蛍光タンパク質脳内局在の検討2013
Author(s)
井樋慶一,Ashraf H. Talukder,布施俊光,杉本直哉,小澤遼,内田克哉,山崎真弥,阿部学,夏目里恵,崎村建司
Organizer
包括的ネットワーク夏のワークショップ
Place of Presentation
名古屋国際会議場,名古屋
Year and Date
2013-08-30
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[Presentation] Histological characterization of mice expressing fluorescent proteins selectively in the corticotropin-releasing factor neurons in the brain2013
Author(s)
Ashraf H. Talukder, Toshimitsu Fuse, Junko Kono, Naoya Sugimoto, Ryo Ozawa, Katsuya Uchida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kenji Sakimura, Keiichi Itoi
Organizer
第36回日本神経科学学会
Place of Presentation
京都国際会議場,京都
Year and Date
2013-06-10
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[Presentation] Immunocytochemical characterization of the mouse brain expressing fluorescent proteins selectively in the corticotropin-releasing factor neurons2013
Author(s)
Ashraf H. Talukder, Toshimitsu Fuse, Junko Kono, Naoya Sugimoto, Ryo Ozawa, Katsuya Uchida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kenji Sakimura, Keiichi Itoi
Organizer
NIH-Tohoku University-JSPS Symposium
Place of Presentation
Gonryo-Kaikan, Sendai
Year and Date
2013-05-10
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[Presentation] A microarray-based screen for transcription factors expressed in fetal pontine noradrenergic neurons and examination of their functional roles in catecholamine-synthesizing enzyme gene expression2012
Author(s)
T. Fuse, K. Uchida, H. Yokohashi, T. Aiyoshizawa, Y. Iwasaki, K. Kinoshita, G. Das, C. Tanaka, H. Tomita, S. Ohara, K. Kobayashi, K. Itoi
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, LA, USA
Year and Date
2012-10-14
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[Presentation] Generaton of corticotropin-releasing factor (CRF)-Venus knock-in mouse for studying the regulatory mechanism of CRF neurons in the paraventricular nucleus of the hypothalamus2012
Author(s)
Sugimoto N, Fuse T, Tsubokawa H, Yamazaki M, Abe M, Natsume R, Uchida K, Das G, Sakimura K, Itoi K
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, LA, USA
Year and Date
2012-10-13
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[Presentation] Screening of transcription factors expressed in the fetal pontine noradrenergic neurons and examination of their functional roles in cathecholamine-synthesizing enzyme gene expression2012
Author(s)
Haruka Yokohashi, Toshimitsu Fuse, Katsuya Uchida, Akihiro Aiyoshizawa, Yasumasa Iwasaki, Kengo Kinoshita, Akira Okazaki, Gopal Das, Keisuke Sawada, Chiaki Tanaka, Hiroaki Tomita, Shinji Ohara, Kazuto Kobayashi, Keiichi Itoi
Organizer
日本神経科学学会
Place of Presentation
名古屋国際会議場,名古屋
Year and Date
2012-09-19
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[Presentation] A FACS-array analysis of transcripts expressed in fetal pontine noradrenergic neurons and identification of transcription factors regulating the enzyme genes involved in catecholamine symteesis2011
Author(s)
Yokohashi H, Fuse T, Uchida K, Sawada K, Aiyoshizawa A, Das G, Tomita H, Tanaka C, Konishidta K, Kobayashi K, Iwasaki Y, Itoi K
Organizer
第34回日本分子生物学会年会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
2011-12-13
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[Presentation] Identification of novel transcription factors for catecholamine gene expression based upon the comprehensive analyses of transcripts in fetal pontine noradrenergic neurons by FACS-array technology2011
Author(s)
Itoi K, Uchida K, Fuse T, Iwasaki Y, Yokohashi H, Okazaki A, Sawada K, Das G, Kobayashi K, Tomita H, Tanaka C, Kinoshita K, Ohara S
Organizer
Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2011-11-16
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