2013 Fiscal Year Final Research Report
Investigation for the nuculear receptor functions to cure clonic inflammatory syndrome
| Project/Area Number |
23591347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Takashi 群馬大学, 生体調節研究所, 准教授 (70344934)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性炎症 / アンドロゲン / 核内受容体 / KOマウス |
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| Research Abstract |
In the present study, we investigated the mechanisms of hormonal action to regulate inflammation in metabolic organs which cause metabolic diseases. The research, we investigated the effect of the hormone on cell inflamed at the same time to analyzed the abnormality in mice lacking the receptor proteins essential for action of the hormone. As a result of research, it has been found possibility that androgen action repress inflammation via complex cellular process. And we are going to study the relationship between the onset of metabolic diseases and hormone secretion decline of older men.
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[Journal Article] Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis2014
Author(s)
Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A
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Journal Title
J Cell Sci
Volume: 127
Pages: 422-431
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[Journal Article] Hypothalamic Sirt1 prevents age asso- -ciated weight gain by improving leptin sensitivity in mice2013
Author(s)
Sasaki T, Kikuchi O, Shimpuku M, Susanti V-Y, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee Y-S, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M and Kitamura T
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Journal Title
Diabetologia
Volume: 57
Pages: 819-831
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[Journal Article] Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi2013
Author(s)
D'Angelo G, Uemura T, Chuang CC, Polishchuk E, Santoro M, Ohvo-Rekilä H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T,Capuani F,Johannes L, Mattjus P, Monti M, Pucci P, Williams RL, Burke JE, Platt FM, Harada A, De Matteis MA
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Journal Title
Nature
Volume: 501
Pages: 116-120
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[Journal Article] The role of VAMP7/TI-VAMP in cell poiarity and lysosomal exocytosis in vivo2011
Author(s)
Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A
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Journal Title
Traffic
Volume: 12
Pages: 1383-93
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