2013 Fiscal Year Final Research Report
Clinical application and the identification of novel autoantibodies in hypopituitarism
| Project/Area Number |
23591354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kobe University |
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Principal Investigator |
IGUCHI GENZO 神戸大学, 医学部附属病院, 助教 (60346260)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Yutaka 神戸大学, 医学(系)研究科(研究院), 講師 (70301281)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 下垂体機能低下症 / 抗Pit-1抗体 / 抗Pit-1抗体症候群 |
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| Research Abstract |
Anti-pituitary-specific transcriptional factor 1 (PIT-1) antibody syndrome is characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with circulating anti-PIT-1 antibodies. To elucidate the involvement of antibody- or cell-mediated immunity in anti-PIT-1 antibody syndrome. Enzyme-linked immunospot (ELISpot) assay revealed the presence of cytotoxic T lymphocytes (CTLs) that specifically reacted to the recombinant PIT-1 protein in the patient's peripheral lymphocytes. This result suggest that the anti-PIT-1 antibody is not a cause but a marker of anti-PIT-1 antibody syndrome, in which CTLs play a pivotal role in the pathogenesis.The prevalence and clinical characteristics of IgG4-related hypophysitis have been clarified.
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Research Products
(29 results)
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[Journal Article] Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome2014
Author(s)
Bando H, Iguchi G, Fukuoka H, Yamamoto M, Takeno RH, Okimura Y, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Tojo K, and Takahashi Y
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Journal Title
J Clin Endocrinol Metab
Volume: (2014/6/5 accepted)
Peer Reviewed
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[Journal Article] A missense single nucleotide polymorphism in the sialic acid acetyl esterase gene is associated with anti-PIT-1 antibody syndrome2014
Author(s)
Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
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Journal Title
DOI
Peer Reviewed
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[Journal Article] The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature2013
Author(s)
Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y
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Journal Title
Eur J Endocrinol
Volume: 170巻
Pages: 161-172
DOI
Peer Reviewed
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[Journal Article] A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression2013
Author(s)
Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
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Journal Title
Mol Cell Endocrinol
Volume: 376巻
Pages: 93-98
DOI
Peer Reviewed
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[Presentation] 頭部外傷後に発症し失神発作をきたしたACTH単独欠損症の一例2014
Author(s)
西澤衡,井口元三,坂東弘教,隅田健太郎,山本雅昭,高橋路子,福岡秀規,廣田勇士,坂口一彦,小川渉,高橋裕
Organizer
第23回臨床内分泌代謝UPDATE
Place of Presentation
名古屋
Year and Date
2014-01-24
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[Presentation] IgG4陽性細胞が認められた肉芽腫性下垂体炎の1例2013
Author(s)
坂東弘教,井口元三,福岡秀規,隅田健太郎,山本雅昭,西澤衡,高橋路子,谷口理章,甲村英二,清野進,高橋裕
Organizer
第86回日本内分泌学会学術総会
Place of Presentation
仙台
Year and Date
2013-04-27
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