2013 Fiscal Year Final Research Report
Nobel quantification system of non-transferrin-bound iron utilizing automated analyzer
| Project/Area Number |
23591363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA Katsuya 旭川医科大学, 医学邪, 講師 (00396376)
OHTAKE Takaaki 旭川医科大学, 医学邪, 特任教授 (10359490)
KOHGO Yutaka 旭川医科大学, 医学邪, 教授 (10133183)
TANAKA Hiroki 旭川医科大学, 医学邪, 特任助教 (70596155)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 鉄 / 不安定鉄 / NTBI / 鉄過剰 / トランスフェリン / HPLC / 自動分析装置 / バイオマーカー |
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| Research Abstract |
Iron overload causes various organ damages. When transferrin is fully saturated, non-transferrin-bound iron (NTBI) appears in the serum. Since NTBI relates to oxidant stress, monitoring serum NTBI levels is crucial for iron-overloaded patients. In the present study, we aimed to develop the novel NTBI measuring reagent corresponding to the automatic analyzer by modifying the high-performance liquid chromatography (HPLC)-based NTBI assay (the gold standard method). The correlation coefficient for NTBI values between our system and HPLC method was 0.923, indicating that the accuracy of our system is comparable to the gold standard method. Our novel NTBI assay system should be a powerful tool for studying physiological and clinical importance of NTBI.
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[Journal Article] Hoerferritinemia after adult allogeneic hematopoietic cell transplantation : quantification of iron burden by determining non-transferrin-bound iron2013
Author(s)
Tatsunori Goto, Katsuya Ikuta, Yoshihiro Inamoto, Sonoko Kamoshita, Emi Yokohata, Daisuke Koyama, Koichi Onodera, Aika Seto, Keisuke Watanabe, Nobuhiko Imahashi, Shokichi Tsukamoto, Yukiyasu Ozawa, Katsunori Sasaki, Masafumi Ito, Yutaka Kohgo and Koichi Miyamura
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Journal Title
Int J Hematol
Volume: 97
Pages: 125-134
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[Journal Article] Iron overload signature in chrysotile-induced malignant mesothelioma2012
Author(s)
Li Jiang, Shinya Akatsuka, Yoriko Yamashita, Hirotak Nagai, Hiroki Ohara, Shan-Hwu Chew, Yasumasa Okazaki, Yutak Yoshikawa, Hiroyuki Yasui, Katsuya Ikuta, Katsunori Sasaki, Yutaka Kohgo, Seishiro Hirano, Yasushi Shinohara, Norihiko Kohyama, Takashi Takahashi, Shinya Toyokuni
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Journal Title
J Pathol
Volume: 228
Pages: 366-377
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[Presentation] Nobel quantification system for non-transferrin-bound iron utilizing automated analyzer2013
Author(s)
Junki Inamura, Katsuya Ikuta, Daisuke Kato, Naomi Iizuka, Yasumichi Toki, Satoshi Ito, Hiroki Tanaka, Katsunori Sasaki, Motohiro Shindo, Yoshihiro Torimoto, Yutaka Kohgo
Organizer
第75回日本血液学会学術集会(JSH2013)
Place of Presentation
札幌
Year and Date
20131011-13
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[Presentation] Nobel quantification system of non-transferrin-bound iron (NTBI) utilizing automatic analyzer2013
Author(s)
Katsuya Ikuta, Satoshi Ito, Lynda Addo, Mayumi Hatayama, Yasumichi Toki, Junki Inamura, Motohiro Shindo, Hiroki Tanaka, Katsunori Sasaki, Yoshihiro Torimoto, Yutaka Kohgo
Organizer
2013 IBIS Meeting BioIron
Place of Presentation
London, UK
Year and Date
20130414-18
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