2013 Fiscal Year Final Research Report
The metabolome analysis of leukemic stem cell
| Project/Area Number |
23591379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OHNISI Kazunori 浜松医科大学, 医学部附属病院, 教授 (80252170)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIE Michio 浜松医科大学, 実験実習機器センター, 技術専門職員 (90397373)
SHIBATA Kiyoshi 浜松医科大学, 実験実習機器センター, 技術専門職員 (80397372)
NAKAMURA Satoki 浜松医科大学, 医学部, 特任研究員 (20377740)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 白血病 / メタボローム解析 / 代謝制御 |
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| Research Abstract |
We investigated the metabolome analysis in leukemic stem/progenitor cells. We found that hexokinase (HK), Phosphofructokinase 1 and 2 (PFK1 and 2) and Pyruvate Kinase (PK) were activated in leukemic stem/progenitor cells. We identified the inhibitors (3-BP, 3PO and Alkinnin) of these kinases as target molecules in leukemic stem/progenitor cells. We showed that these inhibitors inhibited the proliferation of leukemic stem/progenitor cells. We will perform the development of cancer stem cell-specific drugs for leukemia therapy.
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[Journal Article] Japan Adult Leukemia Study Group. Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia : a retrospective analysis of JALSG-APL972013
Author(s)
Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Inaguma Y, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Ishigatsubo Y, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T
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Journal Title
Cancer Sci
Volume: 104(10)
Pages: 1339-1345
DOI
Peer Reviewed
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[Journal Article] Recovery of kidney function by rituximab-based therapy in a patient with Waldenström's macroglobulinemia-related nephropathy presenting cast nephropathy and interstitial lymphocytic infiltration2012
Author(s)
Miwa M, Sakao Y, Ishigaki S, Ono M, Fujikura T, Yasuda H, Suzuki H, Kato A, Nagata Y, Shigeno K, Nakamura S, Ohnishi K, Fujigaki Y
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Journal Title
Intern Med
Volume: 51(13)
Pages: 1725-1730
DOI
Peer Reviewed
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[Journal Article] The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer2012
Author(s)
Natsume H, Shinmura K, Tao H, Igarashi H, Suzuki M, Nagura K, Goto M, Yamada H, Maeda M, Konno H, Nakamura S, Sugimura H
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Journal Title
J Transl Med
Volume: 10
Pages: 97
DOI
Peer Reviewed
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[Journal Article] Bcr-Abl-mediated Raf kinase inhibitor protein suppression promotes chronic myeloid leukemia progenitor cells proliferation2011
Author(s)
Nakamura S, Yagyu T, Takemura T, Tan L, Nagata Y, Yokota D, Hirano I, Shibata K, Fujie M, Fujisawa S, Ohnishi K
Volume
1(3)
Pages
54-66
DOI
Peer Reviewed
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[Journal Article] Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells2011
Author(s)
Nakamura S, Takemura T, Tan L, Nagata Y, Yokota D, Hirano I, Shigeno K, Shibata K, Fujie M, Fujisawa S, Ohnishi K.
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Journal Title
Carcinogenesis
Volume: 32(12)
Pages: 1758-1772
DOI
Peer Reviewed
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[Journal Article] Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia2011
Author(s)
Nakamura S, Nagata Y, Tan L, Takemura T, Shibata K, Fujie M, Fujisawa S, Tanaka Y, Toda M, Makita R, Tsunekawa K, Yamada M, Yamaoka M, Yamashita J, Ohnishi K, Yamashita M
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Journal Title
PLoS One
Volume: 6(11)
Pages: e28011
DOI
Peer Reviewed
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