2013 Fiscal Year Final Research Report
Effects of FGF2 on the leukemia microenvironment in the bone marrow
| Project/Area Number |
23591382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Medical University (2012-2013)
Nagoya University (2011) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAOE Tomoki 名古屋医療センター, 血液内科, 院長 (50217634)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血液腫瘍学 / 血液悪性腫瘍幹細胞 / ニッチェ |
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| Research Abstract |
We examined effects of FGF2 on interaction between leukemia cells and its microenvironment. Significantly fewer AML cells were recovered from cocultures with murine stromal monolayers treated with FGF2 than from control. FGF2 also facilitate the sensitivity of CML cells toward imatinib in the coculture. Accordingly, AML cells in cell cycle quiescent are less in FGF2-treated monolayers than control. We next treated human AML mouse model with Ara-C in combination w/wo FGF2. BM sections from FGF2-treated mice displayed thickened bone trabeculae and an increased number of leukemia cells compared to control. FGF2 did not help leukemia cells survive from Ara-C in the spleen. These observations suggest that the endosteal region consisting of osteoblasts is important for leukemia cells to survive from chemotherapy, and that FGF2 favors leukemia cell in the BM via promoting osteoblast functions.
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