2013 Fiscal Year Final Research Report
Development of novel diagnostic and therapeutic biomarkers for hypereosinophilic syndrome
| Project/Area Number |
23591389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kobe University |
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Principal Investigator |
SADA AKIKO 神戸大学, 医学(系)研究科(研究院), 研究員 (90467655)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Toshimitsu 神戸大学, 医学研究科, 准教授 (10219371)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 好酸球増多症候群 / チロシンキナーゼ / リン酸化プロテオミクス |
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| Research Abstract |
Hypereosinophilic syndrome (HES) is a heterogeneous disorders characterized by prolonged eosinophilia with causes unknown. We clarified the clinical differential diagnosis of the patients who participated in this study, and tested for the existence of FIP1L1-PDGFRA chimeric mRNA by RT-PCR. Moreover, we also performed phosphoproteomic studies by mass spectrometry (nanoLC-MS/MS) using the phsphopeptides extracted from peripheral blood of various patients and found the different profiles with which correlate the underlying condition of eosinophilia. This information of phosphopeptides could be useful in the differential diagnosis of HES.
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