2013 Fiscal Year Final Research Report

Development of antigen-specific T cell immunotherapy using iPS cells of antigen-specific T cell origin

Research Project

Project/Area Number	23591413
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Hematology
Research Institution	Kyoto University (2012-2013) The University of Tokyo (2011)
Principal Investigator	KANEKO Shin 京都大学, iPS細胞研究所, 准教授 (40361331)
Project Period (FY)	2011 – 2013
Keywords	抗原特異的T細胞 / iPS細胞 / T細胞分化 / 免疫再生治療
Research Abstract	Antigen-specific T cells play a central role for protecting a host against various type of pathogen including neoplastic tumor and viral infections. There are many cell therapeutic approaches using ex vivo expanded immune cells including antigen-specific T cells of cancer or chronic viral infection patients, however, expansion related T-cell senescence causes severe decrease of therapeutic efficacy. To overcome the problem, we have focused on iPS cells as source of antigen specific T cells and successfully we have developed a method to obtain rejuvenated CD8 single positive T cells preserving antigen-specificity of original T cells by using of plurypotent reprogramming technology. Such rejuvenated CD8 T cells were revealed to have enough function as cytotoxic T cells (Nishimura T et al., Cell Stem Cell 12;114-126, 2013).