2013 Fiscal Year Final Research Report
The alteration of sugar chain profiling during the differentiation into IL-17-producing helper T cells
| Project/Area Number |
23591438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRASHIMA Mitsuomi 香川大学, 医学部, 教授 (70109700)
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| Co-Investigator(Renkei-kenkyūsha) |
NIKI Toshiro 香川大学, 医学部, 助教 (40558508)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ガレクチン９ / Ｔｈ１７細胞 / 糖鎖 |
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| Research Abstract |
It has been reported that the activation of Th17 cells is one of the genesis of autoimmune inflammation. Galectin-9, which is a B-galactoside binding animal lectin inhibits the differentiation of Th17 cells from naive helper T cells. The inhibitory effect of galectin-9 on Th17 differentiation is exerted by binding to the O-linked protein that is relatively specific. Furthermore helper T cells that express galectin-9 on the surface highly secrete galectin 9, and inhibit the differentiation Th17 cells.
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[Journal Article] Galectin-9 Attenuates Acute Lung Injury by Expanding CD14^- Plasmacytoid Dendritic Cell-Like Macrophages2011
Author(s)
K. Kojima, T. Arikawa, N. Saita, E. Goto, Tsumura, R. Tanaka, A. Masunaga, T. Niki, S. Oomizu, M. Hirashima, H. Kohrogi
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Journal Title
American journal of respiratory and critical care medicine
Volume: 184(3)
Pages: 328-39
DOI
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