2013 Fiscal Year Final Research Report
Analysis of a mechanism of neutrophil extracellular trap (NET) fromation and a role of NETs in infectious and inflammatory diseases.
| Project/Area Number |
23591474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMASHITA KOUHEI 京都大学, 医学(系)研究科(研究院), 講師 (80402858)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 好中球細胞外トラップ / NADPH oxidase / 一重項酸素 / 血栓性微小血管障害 / 造血幹細胞移植 / 高尿酸血症 / 心血管障害 / 殺菌 |
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| Research Abstract |
Neutrophil extracellular traps (NETs), a newly recognized extracellular killing mechanism by activated neutrophils, contribute to host defense, however, it is reported to be relevant to the pathogenesis of immunothrombosis and inflammatory/ autoimmune diseases by releasing potent hazarous mediators, such as anti-microbial peptides. In this study, we revealed three major findings as below; 1) Siglet oxygen, one of the reactive oxygen species produced by activated neutrophils, is essential for NET formation, 2) Serum NET levels predict thrombotic microangiopathy after allogeneic stem cell transplantaion (SCT), which is one of the critical complications of SCT. 3) Uric acid induces NADPH oxidase-independent NET formation, suggesting that NETs could be a missing link between serum uric acid elevation and cardiovascular diseases.
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