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2013 Fiscal Year Final Research Report

The analysis of host response determining the severe influenza and HIV infection.

Research Project

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Project/Area Number 23591477
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionThe University of Shiga Prefecture (2012-2013)
The University of Tokushima (2011)

Principal Investigator

YANO mihiro  滋賀県立大学, 人間文化学部, 教授 (40304555)

Co-Investigator(Renkei-kenkyūsha) KIDO Hiroshi  徳島大学, 疾患酵素学研究センター, 特任教授 (50144978)
CHIDA Junji  徳島大学, 疾患酵素学研究センター, 助教 (20437651)
Project Period (FY) 2011 – 2013
Keywordsインフルエンザ脳症 / エイズ脳症 / 高病原性鳥インフルエンザ / プロテアーゼ / ストレス蛋白質
Research Abstract

The vascular endothelial cell hyperpermeability seen in severe influenza is based on the disruption of adherence junctions between cells by influenza virus infection. In this study, we have shown the mechanisms of hyperpermeability of human vein endothelial cells infected with influenza A virus (PR8).The levels of beta catenin, a key regulatory component of the endothelial-cadherin cell adhesion complex, were markedly decreased during infection with increment of vascular hyperpermeability. Since the N-terminus phosphorylation of beta-catenin by GSK-3beta is the initiation step of proteasome-dependent degradation, we examined the effects of GSK-3beta suppression by RNAi. IAV infection-induced beta-catenin degradation was significantly inhibited in GSK-3beta-knockdown cells. These findings suggest that IAV infection induces GSK-3beta-mediated beta-catenin degradation in the adherence junctions and induces vascular hyperpermeability.

  • Research Products

    (10 results)

All 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 702014

    • Author(s)
      H Endo. M Yano. Y Okumura. H Kido
    • Journal Title

      Cell Death and Disease

      Volume: 5 Pages: e1027

    • Peer Reviewed
  • [Journal Article] Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo2013

    • Author(s)
      M Inoue. K Yasuda. H Uemura. N Yasaka. H Inoue. A Schnaufer. M Yano. H Kido. D Kohda. H Doi. T Fukuma. A Tsuji. N Horikoshi
    • Journal Title

      J Biochem

      Volume: 153(5) Pages: 431-439

    • Peer Reviewed
  • [Journal Article] Induction and maintenance of anti-influenza antigen-specific nasal secretory IgA levels and serum IgG levels after influenza infection in adults2012

    • Author(s)
      C Fujimoto. N Takeda. A Matsunaga. A Sawada. T Tanaka. T Kimoto. W Shinahara. T Sawabuchi. M Yamaguchi. M Hayama. H Yanagawa. M Yano. H Kido
    • Journal Title

      Influenza Other Respi Viruses

      Volume: 6(6) Pages: 396-403

    • Peer Reviewed
  • [Journal Article] Role of host cellular proteases in the pathogenesis of influenza and influenza -induced multiple organ failure2012

    • Author(s)
      H Kido. Y Okumura. E Takahashi. HY Pan. S Wang. D Yao. M Yao. J Chida J. M Yano
    • Journal Title

      Biochim Biophys Actta

      Volume: 1824(1) Pages: 186-94

    • Peer Reviewed
  • [Journal Article] インフルエンザ重症化と脳症の分子機構2011

    • Author(s)
      矢野仁康, 木戸博
    • Journal Title

      化学療法の領(医薬ジャーナル社)

      Volume: Vol.27.No.12 Pages: 54-60

  • [Journal Article] Up-regulation of ectopic trypsins in the myocardiumby influenza Avirus infection triggers acute myocarditis2011

    • Author(s)
      H-P Pan, M Yano, H Kido
    • Journal Title

      Cardiovasc Res

      Volume: 89 Pages: 595-603

    • Peer Reviewed
  • [Journal Article] Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity2011

    • Author(s)
      D Mizuno. T Kimoto. T Takei. A Fukuta. W Shinahara. T Takahashi. M Yano. H Kido
    • Journal Title

      Vaccine

      Volume: 26 Pages: 5368-5679

    • Peer Reviewed
  • [Presentation] 酵素と感染症:タンパク質分解酵素によるインフルエンザ重症化機序2013

    • Author(s)
      矢野仁康
    • Organizer
      日本栄養・食糧学会第52回近畿支部大会
    • Place of Presentation
      彦根
    • Year and Date
      20130000
    • Invited
  • [Presentation] ヒト内皮細胞に感染したインフルエンザウイルスは、アドヘレンスジャンクションの崩壊を誘導する2012

    • Author(s)
      日吉峰麗, 矢野仁康、木戸博
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20120000
  • [Presentation] インフルエンザ感染の重症化促進因子、血管内皮細胞の細胞間接着に与えるウイルス感染と解熱剤の障害促進効果の解析2011

    • Author(s)
      日吉峰麗, 矢野仁康、木戸博
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      20110000

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Published: 2015-07-16  

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