Protective effects of Ketone-bodies against demyelinating disease

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Ehime University
• Principal Investigator: SUZUKI Yuka 愛媛大学, 医学(系)研究科(研究院), 寄附講座准教授 (00304634)
• Co-Investigator(Kenkyū-buntansha): FUKUDA Mitsumasa 愛媛大学, 医学部附属病院, 准教授 (80274330) ; TANAKA Junya 愛媛大学, 大学院医学系研究科, 教授 (70217040)
• Project Period (FY): 2011 – 2013
• Keywords: ケトン体エステル / 脱随疾患 / ケトン食療法 / EAEマウスモデル

Research Abstract

We have analyzed ketone-bodies effect on experimental autoimmune encephalomyelitis (EAE) mouse model. To design most physiological and stable administration method, we experimented several methods. We synthesized the ketone ester, R, S-1, 3-butanediol acetoacetate diester (BD-AcAc2). BD-AcAc2 was administered orally and blood Acetone and beta-hydroxybutylate level were increased. Extreme acidosis caused high mortality rate and we were unable to get stable results.