2013 Fiscal Year Final Research Report
The role of biological clock in fetal programming by maternal overnutrition
| Project/Area Number |
23591526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health |
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Principal Investigator |
KAWAI Masanobu (カワイ マサノブ) 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 研究員 (50598117)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 概日リズム / 胎児期プログラミング / PPARガンマ |
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| Research Abstract |
Fetal exposure to high fat diet (HFD) has been implicated in metabolic syndrome in later life.In addition, accumulating evidence indicates the critical role of biological clock in the development of metabolic syndrome. Based on these, the effect of fetal exposure to HFD on the circadian rhythm of genes involved in glucose and lipid metabolism was analyzed. Fetal exposure to HFD caused a significant increase in the fat accumulation in the abdomen accompanied by the impaired glucose tolerance and insulin sensitivity. Expression profile of Pparg showd the circadian pattren in the epididymal adipose tissue with lower expression during the dark phase, whereas its expression was enhanced in mice exposed to HFD during fetal period. These findings suggest that the alteration of Pparg expression profile may have a significant impact on the development of metabolic syndrome in mice exposed to HFD during fetal life.
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[Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development2013
Author(s)
Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T
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Journal Title
Hepatol Res
Volume: 43(11)
Pages: 1211-23
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[Journal Article] Altered thermogenesis and impaired bone remodeling in Misty mice2013
Author(s)
Motyl KJ, Bishop KA, DeMambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ
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Journal Title
J Bone Miner Res
Volume: 28(9)
Pages: 1885-97
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