2013 Fiscal Year Final Research Report
Relationship between allergic diseases and gene expression and epigenetics of umbilical cord-derived cells
| Project/Area Number |
23591529
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tohoku University (2012-2013)
Chiba University (2011) |
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Principal Investigator |
YOICHI Suzuki 東北大学, 東北メディカル・メガバンク機構, 教授 (80216457)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOJO Naoki 千葉大学, 医学(系)研究科(研究院), 教授 (40221303)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アレルギー / アトピー性皮膚炎 / 臍帯 / TSLP / IL-33 / IL-25 / インターフェロン / ブドウ球菌 |
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| Research Abstract |
We have made a birth cohort to study relationship between several phenotypes of infants and sensitization, atopic dermatitis (AD), wheezing at one year of age. We cultured fibroblasts from cords of the newborns. We also investigated colonization of Staphylococcus aureus on cheeks of infants.
Responses of cord-derived fibroblast to RS virus, Rhino virus, and parainfluenza virus showed a different cytokine excretion pattern. Colonization of Staphylococcus aureus at 6 months of age was significantly associated with AD development.
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[Journal Article] Maternal intake of Natto, a Japan's traditional fermented soybean food, during pregnancy and the risk of eczema in Japanese babies2014
Author(s)
Ozawa N, Shimojo N, Suzuki Y, Ochiai S, Nakano T, Morita Y, Inoue Y, Arima T, Suzuki S & Kohno Y.
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Journal Title
Allergol Int
Volume: 63
Pages: 261-266
Peer Reviewed
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[Journal Article] Functional variants in the thromboxane A2 receptor gene are associated with lung function in childhood-onset asthma2013
Author(s)
Takeuchi K, Mashimo Y, Shimojo N, Arima T, Inoue Y, Morita Y, Sato K, Suzuki S, Nishimuta T, Watanabe H, Hoshioka A, Tomiita M, Yamaide A, Watanabe M, Okamoto Y, Kohno Y, Hata A & Suzuki Y.
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Journal Title
Clin Exp Allergy
Volume: 43
Pages: 413-24
Peer Reviewed
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[Journal Article] Association study of matrix metalloproteinase-12 gene polymorphisms and asthma in a Japanese population2012
Author(s)
Yamaide F, Undarmaa S, Mashimo Y, Shimojo N, Arima T, Morita Y, Hirota T, Fujita K, Miyatake A, Doi S, Sato K, Suzuki S, Nishimuta T, Watanabe H, Hoshioka A, Tomiita M, Yamaide A, Watanabe M, Okamoto Y, Kohno Y, Tamari M, Hata A & Suzuki Y.
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Journal Title
Int Arch Allergy Immunol
Volume: 160
Pages: 287-96
Peer Reviewed
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