2013 Fiscal Year Final Research Report
The cytotoxic effect by natural killer cells against pediatric malignant solid tumors
| Project/Area Number |
23591532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
GOI Kumiko 山梨大学, 医学部附属病院, 講師 (70324192)
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| Project Period (FY) |
2011 – 2013
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| Keywords | NK細胞 / 小児固形腫瘍 / 同種移植 |
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| Research Abstract |
We analyzed the effect and the mechanisms of the cytotoxicity of NK cells against pediatric solid tumors. The surface expressions of HLA class I as ligand of NK inhibitory receptors in neuroblastoma cell lines were significantly lower than ones in the other tumor cell lines. The expressions of the ligands of NK activating receptor were also low in neuroblastoma cells, but slightly high in some other tumor cells. We confirmed the cytotoxicities of NK cells against the neuroblastoma and malignant rhabdoid tumor. However, the effects by the mismatch of HLA-C group between donor NK cells and target tumor cells were not significant in this cytotoxicities.
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