The effect of genetic and enviromental factor to the development of bronchial asthma

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591534
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Gifu University
• Principal Investigator: MATSUI Eiko 岐阜大学, 医学部附属病院, 講師 (90334929)
• Project Period (FY): 2011 – 2013
• Keywords: アレルギー / 環境因子 / 遺伝子

Research Abstract

The purpose of this research is to examine the interaction of the genetic and environmental factors with allergy disease. Therefore, detaile questionnaire of the environment factors before birth and after birth was corrected.Moreover, a lymphocyte surface marker and gene polymorphism were examined using umbilical cord blood and the peripheral blood.
When the episode of wheezing and the family history of bronchial asthma was positive, the rate of bronchial asthma was high by the follow-up to 3 years old.
In gene polymorphism, when ADRB2 (R16G) was AA type, the rate of bronchial asthma was high.

Research Products

• [Journal Article] Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months (2013)
  • Author(s): Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, Arai T MD, Kondo M, Kawamoto M, Matsui E, Orii K, Kasahara K, Takemura M, Seishima M, Shiraki M, Iwasa S, Kondo N
  • Journal Title: Allergy Asthma Proc Volume: 34 Pages: 362-369
  • Peer Reviewed
• [Journal Article] In Vitro Analysis of the Functional Effects of an NLRP3 G809S Variant with the co-Existence of MEFV Haplotype Variants in Atypical Autoinflammatory Syndrome (2013)
  • Author(s): Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N.
  • Journal Title: J Clin Immunol Volume: 33 Pages: 325-34
  • Peer Reviewed
• [Journal Article] Repeated-Dose Pharmacokinetics of Inhaled Ciclesonide (CIC-HFA) in Japanese Children with Bronchial Asthma : A Phase I Study (2012)
  • Author(s): Teramoto T, Matsui E, Fukao T, Sakai K, Yonezawa H, Kato Z, Ohnishi H, Kaneko H, Kondo N, Azuma J, Nishima S.
  • Journal Title: Allergol Int Volume: 61 Pages: 619-624
  • Peer Reviewed
• [Journal Article] 喘息/COPD基礎研究最前線遺伝子検索による喘息、アレルギー疾患発症のテーラーメイド的予知および予防指導の試み (2012)
  • Author(s): 松井永子、木全かおり、大西秀典、加藤善一郎、金子英雄、近藤直実
  • Journal Title: International Review of Asthma and COPD Volume: 14 Pages: 23-28
• [Presentation] 発症予防の遺伝子ターゲット (2013)
  • Author(s): 松井永子
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 20130511-12
• [Presentation] アレルギー発症のテーラーメイド予知予防 (2013)
  • Author(s): 松井永子
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 20130511-12
• [Presentation] アレルギー疾患のテーラーメイド医療をめざして (2012)
  • Author(s): 松井永子
  • Organizer: 第49回日本小児アレルギー学会
  • Place of Presentation: 大阪
  • Year and Date: 20120915-16
• [Presentation] 気管支喘息のテーラーメイド的予知および予防指導の試み (2012)
  • Author(s): 松井永子, 木全かおり, 篠田紳司, 金子英雄, 加藤善一郎, 近藤直実
  • Organizer: 第24回日本アレルギー学会春季臨床大会
  • Place of Presentation: 大阪
  • Year and Date: 20120512-13
• [Presentation] 小児喘息の個別化予防指導および個別化治療を目指して (2011)
  • Author(s): 松井永子
  • Organizer: 第48回日本小児アレルギー学会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-28
• [Book] 喘息アレルギーのテーラーメイド治療 (2013)
  • Author(s): 近藤直実, 松井永子
  • Total Pages: 1-196
  • Publisher: 診断と治療社