2013 Fiscal Year Final Research Report
The pathophysiology of EB virus infection, and screening investigational drugs using a new human tissue model
| Project/Area Number |
23591564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO Yoshinori 名古屋大学, 医学部附属病院, 講師 (20373491)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Epstein-Barr ウイルス / ヒト組織モデル / ラパマイシン / mTOR |
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| Research Abstract |
Epstein-Barr virus (EBV) causes intractable diseases, including EBV-associated malignancies. Using a new human tissue model, EBV-infected cells were analyzed during the early stage of infection. Naive and memory B cells were found to be infected with EBV. The potential effects of the investigational drugs bortezomib, rapamycin, and mogamulizumab were analyzed using the human tissue model and a murine xenograft model. They showed therapeutic effects in the models.
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[Journal Article]
Author(s)
Kimura, H, Ito Y, Kawabe S, et al
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Journal Title
伊藤嘉規.医学書院、今日の小児治療指Epstein-Barr virus (EBV)-associated T/NK針(第15版)、2012、1001(311-312). lymphoproliferative diseases in non-immunocompromised hosts : prospective6.研究組織analysis of 108 cases, Blood 119(3):673-686,(1)研究代表者2012
DOI
Peer Reviewed
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