2013 Fiscal Year Final Research Report
Role of phospholipase C epsilon in ultraviolet-induced skin carcinogenesis, skin inflammation, cataract, and psoriasis
Project/Area Number |
23591645
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Kobe University |
Principal Investigator |
OKA Masahiro 神戸大学, 医学(系)研究科(研究院), 准教授 (30252761)
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Co-Investigator(Kenkyū-buntansha) |
EDAMATSU Hironori 神戸大学, 大学院医学研究科, 助教 (70335438)
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Project Period (FY) |
2011 – 2013
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Keywords | ホスホリパーゼC / 紫外線 / 皮膚 / 乾癬 / 発癌 / 白内障 / マウス / 角膜 |
Research Abstract |
Phospholipase C (PLC) epsilon is a phosphoinositide-specific PLC regulated by small GTPases including Ras and Rap. In order to investigate the role of PLCe in the skin, we created transgenic mice overexpressing PLCe in epidermal leratinocytes (K5-PLCe-TG). The resulting transgenic mice spontaneously developed skin inflammation as characterized by formation of adherent silvery scales, acanthosis, parakeratosis, and infiltration of neutrophils in the epidermis, and aberrant infiltration of immune cells such as T cells and dendritic cells. When mice were irradiated with ultraviolet B, most wild mice developed erosions and ulcers in the skin, whereas the K5-PLCe-TG mice were resistant to UVB-induced skin damages. In addition, it was revealed that the ability of wound healing in the K5-PLCe-TG mice is increased compared to that in wild mice.
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[Journal Article] Diffuse plane normolipemic xanthoma associated with chronic myelomonocytic leukemia-12014
Author(s)
Oka, M., Okamura, A., Kawano, S., Fukumoto, T., Sakaguchi, M., Nishigori, C
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Journal Title
Eur. J. Dermatol.
Volume: 24(1)
Pages: 112-113
DOI
Peer Reviewed
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[Journal Article] Influence of neutralizing antibodies to adalimumab and infliximab on the treatment of psoriasis2014
Author(s)
Bito, T., Nishikawa, R., Hatakeyama, M., Kikusawa, A., Kanki, H., Nagai, H., Sarayama, Y., Ikeda, T., Yoshizaki, H., Seto, H., Adachi, A., Horikawa, T., Oka, M., Nishigori, C.
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Journal Title
Br. J. Dermatol.
Volume: 170(4)
Pages: 922-929
DOI
Peer Reviewed
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[Journal Article] Onychomycosis as a warning sign for peripheral arterial disease2013
Author(s)
Fukunaga, A., Washio, K., Ogura, K., Taguchi, K., Chiyomaru, K., Ohno, Y., Masaki, T., Nagai, H., Nagano, T., Oka, M., Nishigori, C.
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Journal Title
Acta Derm. Venereol.
Volume: 93(6)
Pages: 747-748
DOI
Peer Reviewed
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[Journal Article] Complete clinical remission of tumor-stage granulomatous mycosis fungoides after treatment with PUVA, skin electron irradiation, oral retinoid, and systemic interferon-γ2013
Author(s)
Yamada, Y., Oka, M., Fujiwara, S., Nishioka, E., Okamoto, Y., Hayashibe, K., Nishigori, C.
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Journal Title
Int. J. Dermatol.
Volume: 52(7)
Pages: 893-895
DOI
Peer Reviewed
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[Journal Article] IgG4-related skin manifestations in patients with IgG4-related disease2013
Author(s)
Ikeda, T., Oka, M., Shimizu, H., Hatakeyama, M., Kanki, H., Kunisada, M., Tsuji, G., Morinobu, A., Kumagai, S., Azumi, A., Negi, A., Nishigori, C.
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Journal Title
Eur. J. Dermatol.
Volume: 23(2)
Pages: 241-245
DOI
Peer Reviewed
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[Journal Article] A case of multiple facial clear cell acanthoma.successfully treated with cryotherapy2013
Author(s)
Hatakeyama, A., Oka, M., Fukunaga, A., Kunisada, M., Funasaka, Y., Nishigori, C.
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Journal Title
Indian J. Dermatol.
Volume: 58(2)
Pages: 162
DOI
Peer Reviewed
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[Journal Article] Case of recurrent Sweet's syndrome in a patient with relapsing polychondritis and myelodysplastic syndrome2012
Author(s)
Washio, K., Oka, M., Ohno, K., Shimizu, H., Kawano, S., Kunisada, M., Nishigori, C.
Volume
39(8)
Pages
731-733
DOI
Peer Reviewed
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[Journal Article] Peristomal skin ulcer with intestinal metaplasia2012
Author(s)
Ono, R., Oka, M., Sakaguchi, M., Nishioka, E., Kawakami, F., Nagano, T., Kunisada, M., Nishigori, C.
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Journal Title
P. Br. J. Dermatol.
Volume: 167(1)
Pages: 204-206
DOI
Peer Reviewed
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[Journal Article] Drug fever due to S-carboxymethyl-L-cysteine : The demonstration of a causative agent with patch tests2012
Author(s)
Hatakeyama, M., Fukunaga, A., Shimizu, H., Oka, M., Horikawa, T., Nishigori, C.
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Journal Title
J. Dermatol.
Volume: 39(6)
Pages: 555-556
DOI
Peer Reviewed
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[Journal Article] Phospholipase Cεhas a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC2011
Author(s)
Oka, M., Edamatsu, H., Kunisada, M., Hu, L., Takenaka, N., Sakaguchi, M., Kataoka, T., Nishigori, C.
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Journal Title
Lab. Invest.
Volume: 91(5)
Pages: 711-718
DOI
Peer Reviewed
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[Journal Article] Overexpression of phospholipase Cεin keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration2011
Author(s)
Takenaka, N., Edamatsu, H., Suzuki, N., Saito, H., Inoue, Y., Oka, M., Hu, L., Kataoka T.
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Journal Title
Eur. J. Immunol.
Volume: 41(1)
Pages: 202-213
DOI
Peer Reviewed
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[Journal Article] Primary cutaneous small cell carcinoma of the vulva arising from squamous cell carcinoma2011
Author(s)
Matsumoto, R., Bito, T., Washio, K., Ikeda, T., Oka, M., Manabe, T., Nishigori, C.
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Journal Title
Br. J. Dermatol.
Volume: 165(5)
Pages: 1147-1148
DOI
Peer Reviewed
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[Journal Article] Eccrine angiomatous hamartoma with sudden enlargement and pain in an adolescent girl after menarche2011
Author(s)
Kikusawa, A., Oka, M., Taguchi, K., Shimizu, H., Kunisada, M., Nishigori, C.
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Journal Title
Dermatoendocrinol
Volume: 3(4)
Pages: 266-268
DOI
Peer Reviewed
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[Journal Article] Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria2011
Author(s)
Kozaru, T., Fukunaga, A., Taguchi, K., Ogura, K., Nagano, T., Oka, M., Horikawa, T., Nishigori, C.
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Journal Title
Allergol. Int.
Volume: 60(3)
Pages: 277-281
DOI
Peer Reviewed
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[Journal Article] Multiple apocrine poromas : A new case report
Author(s)
Nishioka, M., Kunisada, M., Fujiwara, N., Oka, M., Funasaka, Y., Nishigori, C.
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Journal Title
J. Cutan. Pathol.
Volume: (in press)
Peer Reviewed
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[Presentation] Clinical and histopathological features of IgG4-related skin manifestations in patients with IgG4-related disease2013
Author(s)
Masahiro Oka, Tetsuya Ikeda, Hideki Shimizu, Mayumi Hatakeyama,Haruhisa Kanki, Makoto Kunisada, Goh Tsuji, Akio Morinobu, Shunichi Kumagai,Atsushi Azumi, Akira Negi, Chikako Nishigori
Organizer
International Investigative Dermatology Meeting
Place of Presentation
エジンバラ(スコットランド)
Year and Date
20130508-11
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