2013 Fiscal Year Final Research Report
Regeneration of the injured skin by the hair follicle stem cell
| Project/Area Number |
23591653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医療 / 毛包 / 神経 |
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| Research Abstract |
We have previously demonstrated that the stem-cell marker nestin is expressed in hair follicle stem cells. The hair-follicle stem cells are keratin 15-negative and CD34-positive and could differentiate to neurons, glia, keratinocytes, smooth muscle cells and melanocytes in vitro. Subsequently, we showed that the nestin-expressing stem cells could affect nerve and spinal cord regeneration after injection in mouse models. The method described here is appropriate for future use with human hair follicles to produce nestin-expressing hair follicle stem cells in sufficient quantities for nerve and spinal cord regeneration in the clinic.
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