Stem cell therapy for psychiatric disorders using granulocyte-colony stimulating factor

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591678
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: YOSHINAGA TOSHIHIRO 札幌医科大学, 医学部, 研究員 (70404704)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401) ; UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256) ; TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
• Project Period (FY): 2011 – 2013
• Keywords: 精神薬理学 / 顆粒球コロニー刺激因子 / 細胞治療 / 再生医療 / 神経幹細胞 / 神経新生 / 造血幹細胞移植

Research Abstract

The purpose of this study is to develop a possible therapeutic approach for psychiatric disorders by neurogenesis upregulation through increase of peripheral hematopoietic stem cells. First, we have demonstrated that the combined peripheral treatment of stem cells and antidepressant, which has been indicated to increase trophic factors in the serum could have potential to recover the abnormal behavior of treatment-resistant refractory depression model. We have also shown that peripherally treated neural stem cells concentrated much in the hypothalamus areas where oxytocin/vasopresinergic neurons exist, and recovered social/cognitive impairment of psychiatric disease model including parental behavior.

Research Products

• [Journal Article] Stem cell therapy : a new approach to the treatment of refractory depression (2014)
  • Author(s): Kigawa Y, Hashimoto E, Ukai W, Ishii T, Furuse K, Tsujino H, Shirasaka T, Saito T
  • Journal Title: J Neural Transm Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] アルコール性脳障害とうつ病に対するトランスレーショナルリサーチの展望-病態解明と診断の観点から- (2014)
  • Author(s): 鵜飼渉
  • Journal Title: 日本生物学的精神医学会誌 Volume: 25 Pages: 24-26
• [Journal Article] Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells (2013)
  • Author(s): Hashimoto T, Yamada M, Iwai T, Saitoh A, Hashimoto E, Ukai W, Saito T, Yamada M
  • Journal Title: J Neurosci Res Volume: 91 Pages: 1402-1407
  • DOI: 10.1002/jnr.23269
  • Peer Reviewed
• [Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model (2013)
  • Author(s): Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa Y, Tateno M, Kaneta H, Watanabe K, Igarashi T, Kobayashi S, Sohma H, Kato T, Saito T
  • Journal Title: J Neural Transm Volume: 120 Pages: 1491-1498
  • DOI: 10.1007/s00702-013-1010-4
  • Peer Reviewed
• [Journal Article] Stem cell therapy : social recognition recovery in a FASD model (2012)
  • Author(s): Shirasaka T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Saito T
  • Journal Title: Transl Psychiatry Volume: 2 Pages: e188
  • DOI: 10.1038/tp.2012.111
  • Peer Reviewed
• [Journal Article] Antipsychotic induced alteration of growth and proteome of rat neural stem cells (2012)
  • Author(s): Ahmed EU, Ahmed S, Ukai W, Matsumoto I, Kemp A, McGregor IS, Kashem MA
  • Journal Title: Neurochem Res Volume: 37 Pages: 1649-1659
  • DOI: 10.1007/s11064-012-0768-3
  • Peer Reviewed
• [Journal Article] 統合失調症の脳神経回路修復薬物・細胞コンバインド療法の可能性の検討 (2012)
  • Author(s): 鵜飼渉,小野貴文,橋本恵理,金田博雄,白坂知彦,五十嵐健史,木川昌康,渡邊公彦,吉永敏弘,石井貴男,館農勝,小林清樹,齋藤利和
  • Journal Title: 日本生物学的精神医学会誌 Volume: 23 Pages: 109-114
• [Journal Article] Rhotekin modulates differentiation of cultured neural stem cells to neurons (2012)
  • Author(s): Iwai T, Saitoh A, Yamada M, Takahashi K, Hashimoto E, Ukai W, Saito T, Yamada M
  • Journal Title: J Neurosci Res Volume: 90 Pages: 1359-1366
  • DOI: 10.1002/jnr.23029
  • Peer Reviewed
• [Journal Article] 経静脈的神経幹細胞移植によるFASDモデルラットの行動異常改善と脳神経回路シナプス形成の修復 (2012)
  • Author(s): 齋藤利和,鵜飼渉,白坂知彦,橋本恵理,吉永敏弘,金田博雄,五十嵐健史,渡邊公彦,館農勝,石井貴男
  • Journal Title: アルコールと医学生物学 Volume: 31 Pages: 40
• [Presentation] 胎生期アルコール曝露と成長後のストレスを組み合わせた難治性うつ病モデルにおける神経幹細胞移植療法の有効性に関する研究 (2014)
  • Author(s): 鵜飼渉,橋本恵理,木川昌康,石井貴男,古瀬健吾,辻野華子,齋藤利和
  • Organizer: 第33回アルコール医学生物学研究会学術集会
  • Place of Presentation: 高知 (シンポジウム)
  • Year and Date: 20140124-25
• [Presentation] Effects of ethanol and antidepressant on the platelet BDNF release function in the peripheral blood : Implication in the pathogenesis of psychiatric disease (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Takao Ishii, Kigawa Y, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T
  • Organizer: 52nd Annual Meeting of The American College of Neuropsychopharmacology (ACNP)
  • Place of Presentation: Florida
  • Year and Date: 20131208-12
• [Presentation] 薬物療法と神経新生・神経回路修復 (2013)
  • Author(s): 鵜飼渉,橋本恵理,石井貴男,木川昌康,古瀬健吾,辻野華子,吉永敏弘,齋藤利和
  • Organizer: 第26回日本総合病院精神医学会総会
  • Place of Presentation: 京都 (シンポジウム)
  • Year and Date: 20131129-30
• [Presentation] 精神疾患に対する再生医療的アプローチの可能性, 依存研究を基盤にした精神疾患の病因解明の試み (2013)
  • Author(s): 鵜飼渉,橋本恵理,石井貴男,木川昌康,古瀬健吾,辻野華子,白坂知彦,吉永敏弘,小林清樹,齋藤利和
  • Organizer: 第23回日本臨床精神神経薬理学会
  • Place of Presentation: 沖縄 (シンポジウム)
  • Year and Date: 20131024-26
• [Presentation] Stem cell research on Alcoholism. [Symposium] Biomedical Approach on Alcoholism (2013)
  • Author(s): Ukai W, Hashimoto E, Ishii T, Kigawa Y, Yoshinaga T , Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T
  • Organizer: Regional Meeting of Collegium Internationale Neuro-Psychopharmacologicum (CINP)
  • Place of Presentation: Kuala Lumpur
  • Year and Date: 20131002-04
• [Presentation] Alteration of platelet BDNF release function in the peripheral blood : Implications of alcohol and antidepressant (2013)
  • Author(s): Saito T, Hashimoto E, Ukai W, Takao Ishii, Kigawa M, Furuse K, Tsujino H, Kobayashi S, Yoshinaga T
  • Organizer: The 3rd Congress of Asian College of Neuropsychopharmacology (AsCNP)
  • Place of Presentation: Beijing, China
  • Year and Date: 20130911-14
• [Presentation] Basic aspects of alcohol use disorder comorbid with depressive disorder (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Kigawa Y, Yoshinaga T, Watanabe K, Shirasaka T, Tateno M, Kobayashi S, Saito T
  • Organizer: Alcohol abuse comorbidity. 14th Congress of ESBRA
  • Place of Presentation: Warsaw (Symposium)
  • Year and Date: 20130908-11
• [Presentation] Understanding of mechanisms underlying brain abnormality in FASD and its translational approach (2013)
  • Author(s): Ukai W, Hashimoto E, Shirasaka T, Ishii T, Yoshinaga T, Kaneta H, Kigawa Y, Tateno M, Kobayashi S, Saito T
  • Organizer: 14th Congress of ESBRA
  • Place of Presentation: Warsaw (Symposium)
  • Year and Date: 20130908-11
• [Presentation] Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression, Translational perspective on the imaging, epigenetics and peripheral-derived markers for alcohol induced brain damage and depression (2013)
  • Author(s): Hashimoto E, Ukai W, Ishii T, Watanabe K, Shirasaka T, Kaneta H, Kigawa Y, Yoshinaga T, Tateno M, Saito T
  • Organizer: WFSBP Congress of Biological Psychiatry
  • Place of Presentation: Kyoto (Symposium)
  • Year and Date: 20130623-27
• [Presentation] アルコール脳障害の病態理解とその治療的アプローチ (2013)
  • Author(s): 鵜飼渉,橋本恵理,白坂知彦,石井貴男,吉永敏弘,金田博雄,木川昌康,館農勝,齋藤利和
  • Organizer: 依存症発症メカニズムの脳科学.第36回日本神経科学大会第56回日本神経化学会大会第23回日本神経回路学会大会合同大会/Neuro2013
  • Place of Presentation: 京都 (シンポジウム)
  • Year and Date: 20130620-23
• [Presentation] The effect of antipsychotics on GABAergic interneurogenesis in adult brain (2012)
  • Author(s): Ukai W, Kaneta H, Hashimoto E, Igarashi T, Kigawa Y, Shirasaka T, Watanabe K, Yoshinaga T, Tateno M, Ishii T, Saito T
  • Organizer: 28th Collegium Internationale Neuro-Psychopharmacologicum (CINP) Congress
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20120603-07
• [Presentation] Cell-based therapy for alcohol-induce brain damage (2012)
  • Author(s): Ukai W, Shirasaka T, Hashimoto E, Kaneta H, Igarashi T, Watanabe k, Yoshinaga T, Tateno M, Ishii T, Saito T
  • Organizer: The 2nd Congress of Asia-Pacific Society for Alcohol and Addiction Research (APSAAR)
  • Place of Presentation: Bangkok (Symposium)
  • Year and Date: 20120206-08
• [Presentation] Alcohol reduces the effect of antidepressants on platelet BDNF release
  • Author(s): Ishii T, Ukai W, Kigawa Y, Kengo F, Kakutani Y, Hashimoto E, Saito T
  • Organizer: 43nd Annual Meeting of The Society for Neuroscience (SfN)
  • Place of Presentation: San Diego, California
• [Book] 幹細胞療法と精神疾患, メンタル医療 (2013)
  • Author(s): 鵜飼渉,石井貴男,橋本恵理 (糸川昌成監)
  • Total Pages: 193-200
  • Publisher: 東京 : シーエムシー出版
• [Book] 気分障害と幹細胞.躁うつ病の薬理・生化学的研究懇話会編.気分障害の薬理・生化学 (2012)
  • Author(s): 鵜飼渉
  • Total Pages: 145-158
  • Publisher: 大阪 : 医薬ジャーナル社