2013 Fiscal Year Final Research Report
Pathological and biochemical study of dementia as a combined protein accumulation disease
| Project/Area Number |
23591694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ARAI Tetsuaki 筑波大学, 医学医療系, 准教授 (90291145)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Masato (10251232)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 認知症 / 蛋白質 / 蓄積 / 変性 |
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| Research Abstract |
TDP-43, FUS and tau are the major components of the neuronal and glial inclusions in a variety of neurodegenerative disorders. The distributions of these proteins were related to the clinical features in most disorders. The combined accumulation of these proteins frequently occurred in many of neurodegenerative disorders, including frontotemporal lobar degeneration, motor neuron diseases and diffuse neurofibrillary tangles with calcification. Methylene blue reduced tau accumulation in mice harboring tau gene mutation, suggesting that inhibition of tau aggregation by it may have potential as a drug candidate for the treatment of tauopathy. The results of the present study suggest developing the methods to detect each protein in biological fluids may be important for the diagnosis and the disease modifying therapy for the diseases.
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[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia2014
Author(s)
Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
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Journal Title
Acta Neuropathol
Volume: Commun 2
Pages: 40
DOI
Peer Reviewed
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[Journal Article] Prion-like properties of pathological TDP-43 aggregates from diseased brains2013
Author(s)
Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DMA, Akiyama H, Hasegawa M
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Journal Title
Cell Rep
Volume: 4
Pages: 124-134
DOI
Peer Reviewed
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[Journal Article] Pathological features of FTLD-FUS in a Japanese population : Analyses of nine cases2013
Author(s)
Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H
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Journal Title
J Neurol Sci
Volume: 335
Pages: 89-95
DOI
Peer Reviewed
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[Journal Article] Post mortem cerebrospinal fluidα-synuclein levels are raised in multiple system atrophy and distinguish this from the otherα-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies2012
Author(s)
Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DMA
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Journal Title
Neurobiol Dis
Volume: 45
Pages: 188-195
DOI
Peer Reviewed
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[Journal Article] Progressive nonfluent aphasia : a rare clinical subtype of FTLD-TDP in Japan2012
Author(s)
Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
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Journal Title
Neuropathology
Volume: 32
Pages: 272-279
DOI
Peer Reviewed
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[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012
Author(s)
Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuda H, Takao M, Saito Y, Murayama S, Akiyama H, Hasegawa M, Mann DMA, Tamaoka A
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Journal Title
Brain
Volume: 135
Pages: 3380-3391
DOI
Peer Reviewed
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[Journal Article] 32歳で発症した舞踏病様不随意運動を伴う前頭側頭型認知症の一例2012
Author(s)
河上緒, 新里和弘, 新井哲明, 大島健一, 安野みどり, 湯本洋介, 小幡奈々子, 新井誠, 糸川昌成, 後藤順, 市川弥生子, 平安良雄, 岡崎祐士, 秋山治彦
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Journal Title
老年精神医学雑誌
Volume: 23
Pages: 1121-1127
Peer Reviewed
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[Journal Article] N-cadherin regulates p38MAPK signaling via association with JLP : Implications for neurodegeneration in Alzheimer's disease2011
Author(s)
Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
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Journal Title
J Biol Chem
Volume: 286
Pages: 7619-28
DOI
Peer Reviewed
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[Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification–With special reference to TDP-43 proteinopathy and alpha-synucleinopathy–2011
Author(s)
Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
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Journal Title
J Neurol Sci
Volume: 301
Pages: 77-85
DOI
Peer Reviewed
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[Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy cases2011
Author(s)
Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
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Journal Title
Neuropathology
Volume: 31
Pages: 135-143
DOI
Peer Reviewed
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[Journal Article] FALS with Gly72Ser mutation in SOD1 gene : report of a family including the first autopsy case2011
Author(s)
Kobayashi Z, Tsuchiya K, Kubodera T, Shibata N, Arai T, Miura H, Ishikawa C, Kondo H, Ishizu H, Akiyama H, Mizusawa H
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Journal Title
J Neurol Sci
Volume: 300
Pages: 9-13
DOI
Peer Reviewed
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[Presentation] Tau pathology in the parahippocampal region is related to delusion in the elderly : neuropathological study of two autopsy cases2013
Author(s)
Arai T, Kawakami I, Mizukami K, Ikeda K, Oshima K, Niizato K, Kobayashi Z, Hosokawa M, Nonaka T, Hasegawa M, Akiyama H, Asada T
Organizer
Alzheimer's Association International Conference 2013
Place of Presentation
Boston, USA
Year and Date
20130712-17
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[Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties2013
Author(s)
Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H, Hasegawa M
Organizer
Alzheimer's Association International Conference 2013
Place of Presentation
Boston, USA
Year and Date
20130712-17
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[Presentation] Alpha-synuclein pathology in the medulla oblongata in association with the reduction of the ventilatory response to hypercapnia in dementia with Lewy bodies and Parkinson's Disease2013
Author(s)
Takahashi S, Arai T, Mizukami K, Kondo H, Oshima K, Niizato, K, Hosokawa M, Akiyama H, Asada T
Organizer
Alzheimer's Association International Conference 2013
Place of Presentation
Boston, USA
Year and Date
20130712-17
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[Presentation] Pathological background of the ventilatory response to hypercapnia in Dementia with Lewy Bodies and Parkinson's Disease2013
Author(s)
Takahashi S, Arai T, Mizukami K, Kondo H, Oshima K, Niizato, K, Hosokawa M, Akiyama H, Asada T
Organizer
The 11th International Conference on Alzheimer's and Parkinson's disease
Place of Presentation
Florence, Italy
Year and Date
20130306-10
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[Presentation] tangle-predominant dementiaの側座核におけ病理学的検討2013
Author(s)
河上緒, 長谷川成人, 新井哲明, 青木直哉, 勝瀬大海, 東晋二, 大島健一, 新里和弘, 近藤ひろみ, 羽賀千恵, 下村洋子, 山下万貴子, 鈴木京子, 平安良雄, 秋山治彦
Organizer
第54回日本神経病理学会総会学術研究会
Place of Presentation
東京
Year and Date
2013-04-25
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[Presentation] Three autopsy cases of FTD-MND with progressive aphasia2012
Author(s)
Kawakami I, Higashi S, Aoki N, Niizto K, Ohshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
Organizer
The 8^<th> International Conference on Frontotemporal Dementias
Place of Presentation
Manchester, UK
Year and Date
2012-09-15
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[Presentation] Screening of the SOD1, TARDBP and FUS mutations and the pathological studies in Japanese cases with familial and sporadic amyotrophic lateral sclerosis2012
Author(s)
Arai T, Arai M, Itokawa M, Yoshida M, Tamaoka A, Kobayashi Z, Hosokawa M, Hasegawa M, Nonaka T, Tsuji H, Yamada M, Matsui M, Kaji R, Nakashima K, Kuwano R, Takahashi S, Asada T, Akiyama H
Organizer
Alzheimer's Association International Conference 2012
Place of Presentation
Vancouver, Canada
Year and Date
2012-07-15
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[Presentation] ALSとTDP-43の生化学2012
Author(s)
長谷川成人, 野中隆, 辻浩史, 玉岡晃, 吉田眞理, 村山繁雄, Mann David, 新井哲明, 秋山治彦
Organizer
第53回日本神経病理学会総会学術集会
Place of Presentation
新潟
Year and Date
2012-06-30
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[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
Author(s)
Hosokawa H, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
Organizer
Neuroscience 2011
Place of Presentation
Washington, DC, USA
Year and Date
20111112-16
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[Presentation] Histopathological analysis of progranulin knockout mice2011
Author(s)
Arai T, Matsuwaki T, Hasegawa M, Akiyama H, Nonaka T, Hosokawa M, Takahashi S, Mizukami K, Asada T, Nishihara M
Organizer
Alzheimer's Association International Conference 2011
Place of Presentation
Paris, France
Year and Date
2011-07-18
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[Presentation] FTLD-FUSの1剖検例2011
Author(s)
新井哲明, 岩切雅彦, 水上勝義, 畑中公孝, 袖山紀子, 田中芳郎, 山形晃彦, 石井映美, 朝田隆
Organizer
第52回日本神経病理学会総会学術研究会
Place of Presentation
京都
Year and Date
2011-06-03
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