2013 Fiscal Year Final Research Report
Neuropathology of schizophrenia -compare to model animals-
| Project/Area Number |
23591701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
SHUJI Iritani 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (60191904)
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| Co-Investigator(Renkei-kenkyūsha) |
OZAKI Norio 名古屋大学, 大学院医学系研究科, 教授 (40281480)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 統合失調症 / 神経病理 / 死後脳 / モデル動物 |
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| Research Abstract |
The aim of this study is to clarify the pathogenesis of Schizophrenic disorder from the point of view of neuropathological approach. In this period, it has been detected as achievement as follows: 1) Dopaminergic neuronal impairment has been detected in the frontal cortex of genetic modified model animals (mouse) of Schizophrenia. 2) Similarly, it has been detected that the number of GABAergic neurons was reduced in the frontal cortex of the model animals. 3) The vulnerability of the brain tissue in Heschl's gyrus of schizophrenic disease has been detected by the morphometric analysis for the neuropathologocal specimens of post mortem human brain. 4) In the cortex of same area, the decrease of myelin protein was observed. These phenomena may be thought to relate to the volume reduction by neuroimeging observation in this gyrus.
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[Journal Article] Definition and refinement of the 7q36.3 duplication region associated with schizophrenia2013
Author(s)
Aleksic B, Kushima I, Ohye T, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Koide T, Iritani S, Kurahashi H, Iwata N, Ozaki N
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Journal Title
Sci Rep
Volume: 3
Pages: 2587
DOI
Peer Reviewed
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[Journal Article]2012
Author(s)
Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B
Pages: 30-7
DOI
Peer Reviewed
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