2014 Fiscal Year Final Research Report
Development of therapeutic agents for Alzheimer's disease focused by a new modulator of gamma-secretase complex
| Project/Area Number |
23591705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kohei 浜松医科大学, 子どものこころの発達研究センター, 講師 (50588879)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | アルツハイマー病 / プレセニリン / ガンマセクレターゼ / アミロイド / 脳・神経 / 認知症 / ミトコンドリア |
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| Outline of Final Research Achievements |
A-beta is known as a most important molecule of Alzheimer's disease (AD) pathogenesis. We tried to identify a new modulator of gamma-secretase which is the final cutting enzyme of the A-beta production using in vivo crosslink method. As a result, unknown molecule GL was identified as a immunoprecipitant with both presnilin-1 and aph-1 antibodies. It is indicated that GL binds to other gamma-secretase components, and attenuation of GL expression by siRNA decrease A-beta production. These results suggest that regulation of GL expression might be a new therapeutic target for AD prevention or inhibition of its development.
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| Free Research Field |
神経化学
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