2013 Fiscal Year Final Research Report
Pathological bases of schizophrenia-like psychotic disorders in the elderly
| Project/Area Number |
23591708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Okayama University |
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Principal Investigator |
YOKOTA Osamu 岡山大学, 医学部, 客員研究員 (60379732)
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| Project Period (FY) |
2011 – 2013
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| Keywords | タウオパチー / 嗜銀顆粒病 / グレイン性認知症 / レビー小体病 / 精神病性障害 / 統合失調症 / 遅発性統合失調症 |
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| Research Abstract |
We examined the relationship between neurodegenerative diseases including argyrophilic grain disease (AGD) and late-onset schizophrenia-like psychotic disorders (LOSD; onset age>40 years of age). In all LOSD cases (compared to controls), the frequencies of Lewy body disease (LBD), AGD, and corticobasal degeneration (CBD) were 26.1% (11.3%), 21.7% (8.5%), and 4.3% (0.0%), respectively. The total frequency of LBD, AGD, and CBD was significantly higher in LOSD cases than in normal controls. In LOSD patients whose onset occurred at >65 years of age, the frequencies of LBD and AGD were 36.4% (19.4%) and 36.4% (8.3%), respectively, and AGD was significantly more frequent in LOSD patients than in normal controls. Given these findings, AGD may be associated with the occurrence of LOSD.
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[Journal Article] Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia2012
Author(s)
Nagao S, Yokota O, Nanba R, Takata H, Haraguchi T, Ishizu H, Ikeda C, Takeda N, Oshima E, Sakane K, Terada S, Ihara Y, Uchitomi Y
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Journal Title
J Neurol Sci
Volume: 323
Pages: 147–153
DOI
Peer Reviewed
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[Journal Article] Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses : a clinicopathological study2012
Author(s)
Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Katsuya Satoh K, Kitamoto T, Ihara Y, Uchitomi Y
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Journal Title
J Neurol Sci
Volume: 312(1-2)
Pages: 108-16
DOI
Peer Reviewed
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[Presentation] 遅発性精神病性障害を呈す病理背景とその臨床スペクトラム2013
Author(s)
長尾茂人,横田修,池田智香子,大島悦子,石津秀樹,黒田重利,森定ゆみ,須藤浩一郎,中島良彦,寺田整司,内富庸介
Organizer
第28回日本老年精神医学会
Place of Presentation
大阪
Year and Date
2013-06-05
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[Presentation] 晩発性精神病性障害:神経変性疾患の頻度と重症度について2013
Author(s)
長尾茂人,横田修,池田智香子,大島悦子,石津秀樹,黒田重利,森定ゆみ,須藤浩一郎,中島良彦,寺田整司,内富庸介
Organizer
第54回日本神経病理学会総会
Place of Presentation
東京
Year and Date
2013-04-26
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[Presentation] 初期に異常行動と幻覚を認めた皮質基底核変性症とargyrophilic grain diseaseの病理を有した二剖検例2013
Author(s)
池田智香子,横田修,石津秀樹,大島悦子,岸本由紀,武田直也,長尾茂人,坂根克明,寺田整司,森定ゆみ,森定諦,内富庸介
Organizer
第54回日本神経病理学会総会
Place of Presentation
東京
Year and Date
2013-04-25
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[Presentation] 著明な辺縁系・側頭葉萎縮を呈し高度のTDP-43病理とアルツハイマー病理を有した二剖検例2012
Author(s)
武田直也,横田修,石津秀樹,吉田英統,本田肇,大島悦子,岸本由紀,池田智香子,長尾茂人,寺田整司,佐々木健,内富庸介
Organizer
第53回日本神経病理学会総会
Place of Presentation
新潟
Year and Date
2012-06-29
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[Presentation] 体感幻覚や疼痛が前景に立ち認知症を指摘できなかったレビー小体病の二症例2011
Author(s)
岸本由紀,横田修,寺田整司,藤原雅樹,大島義孝,高橋真由美,武田直也,大島悦子,本田肇,石原武士,石津秀樹,高田理恵,藤本明,内富庸介
Organizer
第30回日本認知症学会学術集会
Place of Presentation
東京
Year and Date
2011-11-12
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