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2013 Fiscal Year Final Research Report

Framing a biomaker of prodromal schizophrenia by magnetoencephalography

Research Project

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Project/Area Number 23591713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

MAEKAWA Toshihiko  九州大学, 医学(系)研究科(研究院), 助教 (40448436)

Co-Investigator(Kenkyū-buntansha) ONITSUKA Toshiaki   (00398059)
Co-Investigator(Renkei-kenkyūsha) KANBA Shigenobu   (50195187)
TOBIMATSU Shozo   (40164008)
HIRANO Yoji   (90567497)
HIRANO Shogo   (10568984)
Project Period (FY) 2011 – 2013
Keywords初発統合失調症 / 脳磁図 / 視覚情報処理 / ミスマッチ陰性電位 / バイオマーカー / ウインドミル
Research Abstract

Schizophrenia is often decided by its clinical course and peculiar symptom without biological markers. In this study, automatic brain magnetic response from a visual task in patients with first episode schizophrenia and chronic schizophrenia were tested. In summary, there were no difference of the responses between in first episode schizophrenia and healthy control. However, the response in patients with chronic schizophrenia was declined. Therefore, the brain function of schizophrenia can be estimated objectively by measuring brain magnetic response during our visual task.

  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (10 results) Book (3 results)

  • [Journal Article] Altered visual information processing systems in bipolar disorder : evidence from visual MMN and P32013

    • Author(s)
      Maekawa T, Katsuki S, Kishimoto J, Onitsuka T, Ogata K, Yamasaki T, Ueno T, Tobimatsu S, Kanba S
    • Journal Title

      Front Hum Neurosci

      Volume: 7 Pages: 403

    • DOI

      10.3389/fnhum.2013.0040

    • Peer Reviewed
  • [Journal Article] 統合失調症の視覚ミスマッチ脳磁場反応2013

    • Author(s)
      前川敏彦,中村一太,小原尚利,小田祐子,鬼塚俊明,浦川智和,飛松省三,神庭重信
    • Journal Title

      第28回日本生体磁気学会大会論文集

      Pages: 112-113

    • URL

      http://www.nips.ac.jp/smf/JBBS/ronbun.html

    • Peer Reviewed
  • [Journal Article] サブリミナル顔刺激を用いたアスペルガー症候群の情動刺激処理の解明2013

    • Author(s)
      前川敏彦,黒木俊秀,飛松省三
    • Journal Title

      明治安田こころの健康財団研究助成論文集

      Volume: 48 Pages: 98-114

    • URL

      http://www.my-kokoro.jp/kokoro/books/contents/item_10.php

  • [Journal Article] Rapid maturation of voice and linguistic processing systems in preschool children : A near-infrared spectroscopic study2013

    • Author(s)
      Yamasaki T, Ogata K, Maekawa T, Ijichi I, Katagiri M, Mitsudo T, Kamio Y, Tobimatsu S
    • Journal Title

      Exp Neurology

      Volume: 250 Pages: 313-320

    • DOI

      10.1016/j.expneurol.2013.10.005

  • [Journal Article] Auditory and visual mismatch negativity in psychiatric disorders : a review2012

    • Author(s)
      Maekawa T, Hirano S, Onitsuka T
    • Journal Title

      Curr Psychiatry Rev

      Volume: 8(2) Pages: 97-105

    • DOI

      10.2174/1573400511208020097

    • Peer Reviewed
  • [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia2012

    • Author(s)
      Tsunoda T, Kanba S, Ueno T, Hirano Y, Hirano S, Maekawa T, Onitsuka T
    • Journal Title

      Clin Neurophysiol

      Volume: 123 Pages: 1762-1768

    • DOI

      10.1016/j.clinph.2012.01.024

    • Peer Reviewed
  • [Journal Article] Visual mismatch negativity in psychiatric disorders2012

    • Author(s)
      Maekawa T, Onitsuka T, Tobimatsu S
    • Journal Title

      Int J Psychophysiol

      Volume: 85 Pages: 324

    • DOI

      10.1016/j.ijpsycho.2012.06.095

    • Peer Reviewed
  • [Journal Article] Longitudinal study of sensory information processing in schizophrenia using whole head 306-ch magnetoencephalography2012

    • Author(s)
      Maekawa T
    • Journal Title

      The Report of Study Result by Subsidy, Magnetic Health Science Foundation

      Pages: 34-36

    • URL

      http://www.maghealth.or.jp/file/houkokusyo_japanese2010.pdf

  • [Journal Article] Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients2012

    • Author(s)
      Oda Y, Onitsuka T, Tsuchimoto R, et al
    • Journal Title

      PLoS ONE

      Volume: 7(7) Pages: e39955

    • DOI

      10.1371/journal.pne.0039955

    • Peer Reviewed
  • [Journal Article] Top-down and bottom-up attention in high functioning autism spectrum disorder2011

    • Author(s)
      Maekawa T, Tobimatsu S, Inada N, Oribe N, Onitsuka T, Kanba S, Kamio Y
    • Journal Title

      Res Autism Spectrum Disord

      Volume: 5 Pages: 201-209

    • DOI

      10.1016/j.rasd.2010.03.012

    • Peer Reviewed
  • [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia2011

    • Author(s)
      Tsuchimoto R, Kanba S, Hirano S, et al
    • Journal Title

      Schizophr Res

      Volume: 133 Pages: 99–105

    • DOI

      10.1016/j.schres.2011.07.020

    • Peer Reviewed
  • [Presentation] Altered visual predictive systems in bipolar disorder : evidence from visual MMN and P3002013

    • Author(s)
      Maekawa T, Tobimatsu S, Kanba S
    • Organizer
      2013 Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2013-08-29
  • [Presentation] 統合失調症の視覚ミスマッチ誘発磁場反応2013

    • Author(s)
      前川敏彦,中村一太,小原尚利,小田祐子,鬼塚俊明,浦川智和,飛松省三,神庭重信
    • Organizer
      第28回日本生体磁気学会
    • Place of Presentation
      新潟市
    • Year and Date
      2013-06-08
  • [Presentation] 双極性障害の視覚予期システム異常 : 視覚ミスマッチ陰性電位とP300研究2013

    • Author(s)
      勝木聡美,前川敏彦,鬼塚俊明,飛松省三,神庭重信
    • Organizer
      第10回日本うつ病学会
    • Place of Presentation
      北九州市
    • Year and Date
      2013-06-08
  • [Presentation] 事象関連電位概説2013

    • Author(s)
      前川敏彦
    • Organizer
      第464回福岡臨床と脳波懇話会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-05-15
  • [Presentation] 「回転する蛇」錯視に対する神経磁場活動の時間周波数解析2012

    • Author(s)
      前川敏彦,浦川智和,廣永成人,緒方勝也,飛松省三
    • Organizer
      第41回日本臨床神経生理学会
    • Place of Presentation
      東京都
    • Year and Date
      2012-11-09
  • [Presentation] 統合失調症の視覚ミスマッチ脳磁場の検討 : MEG研究2012

    • Author(s)
      前川敏彦,鬼塚俊明,中村一太,小田祐子,小原尚利,勝木聡美,神庭重信
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-09-29
  • [Presentation] Visual mismatch negativity in psychiatric disorders2012

    • Author(s)
      Maekawa T
    • Organizer
      The 16th World Congress of Psychophysiology of the International Organization of Psychophysiology
    • Place of Presentation
      Pisa, Italy (Symposium)
    • Year and Date
      2012-09-18
  • [Presentation] 「回転する蛇」錯視に関与する神経オシレーション2012

    • Author(s)
      竹田功昴,浦川智和,前川敏彦,廣永成人,緒方勝也,飛松省三
    • Organizer
      第24回臨床神経生理研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2012-08-25
  • [Presentation] 「回転する蛇」錯視に関与する神経オシレーション2012

    • Author(s)
      前川敏彦,浦川智和,廣永成人,緒方勝也,飛松省三
    • Organizer
      神経オシレーション研究会
    • Place of Presentation
      岡崎市
    • Year and Date
      2012-07-12
  • [Presentation] 初発統合失調症の多モダリティーERPs : Boston CIDAR Projectの中間報告2011

    • Author(s)
      前川敏彦,Margaret A. Niznikiewicz, Robert W. McCarley
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-11-12
  • [Book] ミスマッチ陰性電位:臨床応用.モノグラフ脳機能計測法を基礎から学ぶ人のために2013

    • Author(s)
      前川敏彦 (日本臨床神経生理学会認定委員会編)
    • Total Pages
      115-120
    • Publisher
      (東京都)
  • [Book] EEG(誘発電位,脳電図を含む).脳画像でみる精神疾患2013

    • Author(s)
      前川敏彦,鬼塚俊明 (山内俊雄,松田博史編)
    • Total Pages
      111-126
    • Publisher
      新興医学出版社,東京都
  • [Book] Electrophysiology o autism spectrum disorders. Comprehensive guide to autism

    • Author(s)
      Yamasaki T, Maekawa T, Takahashi H, Fujita T, Kamio Y, Tobimatsu S (Colin R. Martin, Victor R. Preedy, Vinood B. Patel (Eds.))
    • Publisher
      Springer, New York

URL: 

Published: 2015-07-16  

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