2014 Fiscal Year Final Research Report
Longitudinal study of Dementia with Lewy bodies
| Project/Area Number |
23591717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Manabu 熊本大学, 生命科学研究部, 教授 (60284395)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | レビー小体型認知症 / 臨床経過 / 症候学 |
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| Outline of Final Research Achievements |
The aim of the present study was to investigate the extended clinical course of dementia with Lewy bodies (DLB). First, sixteen patients had been prospectively followed for 2 years and their cognitive function was assessed by MMSE annually. It became apparent that cognitive function of the patients with DLB could be maintained at least for one year with medication, however, cognitive function declined after 2 years of the baseline assessment despite the continuation of medication. Second, we evaluated the impact of severity of dementia on expression of BPSD in patients with DLB and Alzheimer’s disease (AD). It became evident that the relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects. These findings provide the important information in the management of patients with DLB.
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| Free Research Field |
老年精神医学
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