2013 Fiscal Year Final Research Report
An investigation of neural mechanism of early stage of solvent abuse
| Project/Area Number |
23591725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FUKUI Kenji 京都府立医科大学, 医学(系)研究科(研究院), 教授 (50165263)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 有機溶剤 / MRI |
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| Research Abstract |
This study sought to investigate neural mechanism of formation and maintenance of solvent abuse. We reported a case of solvent abuse who revealed hypofrontality shown by SPECT and frontal dysfunction on neuropsychological tests. We also measured brain activity during reward task using fMRI. We first collected data from healthy subjects to compare with patients. Moreover, we developed new cognitive task that can test performance of patients to relate past experience with current decision making and collected data from normal subjects. These tasks are expected to contribute to reveal the brain mechanism of formation and maintenance of solvent abuse.
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