2013 Fiscal Year Final Research Report
Clinicopathological study on early diagnosis of dementia with Lewy bodies
| Project/Area Number |
23591729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Juntendo University |
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Principal Investigator |
ISEKI Eizo 順天堂大学, 医学部, 教授 (30203061)
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| Co-Investigator(Kenkyū-buntansha) |
FUJISHIRO Hiroki 順天堂大学, 医学部, その他 (20536924)
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| Project Period (FY) |
2011 – 2013
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| Keywords | レビー小体型認知症 / 免疫組織化学 / オートファジー・ライソゾーム系 / 123I-MIBG心筋シンチグラフィー / 18F-FDG PET |
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| Research Abstract |
The aim of this study is to clarify a prodromal state of dementia with Lewy bodies (DLB) and to lead to an early diagnosis and therapy of DLB. From the results of this study, it has been indicated that the patients showing progression to DLB have prodromal symptoms such as RRM sleep behavior disorder, autonomic symptoms, olfactory dysfunction and depression before the onset of cognitive impairment, and that glucose hypometabolism in primary visual cortex on brain FDG-PET and decrease MIBG uptake on MIBG cardiac scintigraphy are already observed in non-demented or mild cognitive impaiment patients with these prodromal symptoms. When patients with prodromal symptoms exhibit characteristic findings on these functional imagings, a preventive therapy should be given for the patients as a prodromal DLB.
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[Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies2012
Author(s)
Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H
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Journal Title
J Neurol Sci
Volume: 314
Pages: 111-119
DOI
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