2013 Fiscal Year Final Research Report
Development of the integrated method for the analysis of brain function by high resolution PET for small animals with the aid of high field MRI
| Project/Area Number |
23591752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
関野 正樹 東京大学, 工学系研究科, 准教授 (20401036)
小島 良紀 独立行政法人国立がん研究センター, がん研究所, 研究員 (20167357)
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| Project Period (FY) |
2011 – 2013
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| Keywords | micro-PET / high field MRI / small animal / brain imaging / molecular imaging / anatomical normalization / PET-CT / mouse |
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| Research Abstract |
The high-resolution PET for small animals is expected to be one of the important tools for the elucidation of the pathophysiology and the innovative drug development of the disease. In this study, we tried to develop the system which enables us to analyze molecular target imaging by micro-PET using high-field MRI. Using a new head fixation device for mouse which can be used commonly both for micro-PET and high-field MRI for small animals, we underwent both MRI and FDG-PET of C57BL mice and made an anatomical delineation on micro-PET imaging after normalization of MRI of each mouse to standard mouse brain atlas. We were able to superimpose a functional image of FDG-PET on an anatomical atlas and calculate regional uptake of FDG over global mean brain uptake. We have found that there was a good correlation between automated method and manual method. It is concluded that automated regional analysis can be applied to the FDG-PET imaging of normal and transgenic mouse brain.
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[Journal Article] J-COSMIC Study Group. Prediction of outcomes in MCI with 123I-IMP-CBF SPECT : a multicenter prospective cohort study2013
Author(s)
Ito K, Mori E, Ishii K, Washimi Y, Asada T, Mori S, Meguro K, Kitamura S, Hanyu H, Nakano S, Matsuda H, Kuwabara Y, Hashikawa K, Momose T, Uchida Y, Hatazawa J, Minoshima S, Kosaka K, Yamada T, Yonekura Y
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Journal Title
Ann Nucl Med
Volume: 27 (10)
Pages: 898-906
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[Presentation] C-11 PiB-PET動態画像を用いた脳内アミロイド蓄積量の全自動解析法の開発2013
Author(s)
百瀬敏光, 髙橋美和子, 相馬努, 佐藤友彦, 古山桂太郎, 北田孝幸, 藤原健太郎, 小島良紀, 井拓也, 加藤誠二, 大友邦
Organizer
第53回日本核医学会学術総会
Place of Presentation
福岡
Year and Date
2013-11-08
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[Presentation] アルツハイマー病、軽度認知機能障害、健常者におけるアミロイド蓄積量の経時的変化に関する検討2012
Author(s)
百瀬敏光, 高橋美和子, 古山桂太郎, 北田孝幸, 藤原健太郎, 加藤誠二, 小島良紀, 相馬努, 荒井拓也, 関本道治, 大友邦
Organizer
第52回日本核医学会学術総会
Place of Presentation
札幌
Year and Date
2012-10-12
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