2013 Fiscal Year Final Research Report
Basic research for non-invasive evaluation of peripheral nerve regeneration by diffusion tensor imaging.
| Project/Area Number |
23591786
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ODA Ryo 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80516469)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Hiroyoshi 京都府立医科大学, 医学研究科, 講師 (90381962)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 末梢神経 / 拡散テンソル法 / 神経再生 |
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| Research Abstract |
Diffusion tensor imaging (DTI) represents a potential diagnostic tool for the peripheral nerve. However, more detailed information is needed for application of DTI in the clinical setting. In this study, peripheral degeneration and regeneration were evaluated using DTI-based analyses in a rabbit model. The changes in DTI parameters were compared to histological and functional changes after nerve injury. We used a high magnetic field (7.04 T) MRI system. Japanese white male rabbits were used as the model of sciatic nerve crush injury. Our results showed that DTI parameters were correlated with axon number and with motor function recovery, assessed with the toe-spreading index. This study clearly demonstrates the validity of applying DTI parameters to the in vivo evaluation of peripheral nerve regeneration. Furthermore, results suggest that DTI can be a potent tool for predicting the extent of functional recovery after peripheral nerve injury.
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[Presentation] In Vivo Evaluation Of Sciatic Nerve Regeneration Of The Male Rabbit With Diffusion Tensor Imaging (DTI) : Correlation With Histology And Behavior2014
Author(s)
Yamasaki T,Fujiwara H, Oda R, Mikami Y, Ikeda T, Nagae M, Shirai T, Morisaki S, Ikoma K, Masugi-Tokita M, Kawata M, Kubo T
Organizer
Orthopaedic Reserch Society Annual meeting 2014
Place of Presentation
New Orleans, USA
Year and Date
2014-03-17
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