2013 Fiscal Year Final Research Report
The Relationship between Visceral Fat, Adipoctokines and colorectal neoplasma development evaluated by computed tomography (CT) colonography
| Project/Area Number |
23591805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Keisuke 川崎医科大学, 医学部, 講師 (10190266)
SHIOTANI Akiko 川崎医科大学, 医学部, 准教授 (80275354)
HARUMA Ken 川崎医科大学, 医学部, 教授 (40156526)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 大腸CT検査 / CTコロノグラフィー / 内臓脂肪型肥満 / 生活習慣病 / アデイポカイン / 大腸腫瘍 |
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| Research Abstract |
• Obesity, visceral fat is associated with increased risks for colorectal neoplasm, cancer (CRC) and adenomatous polyp (polyp). CT colonography(CTC) is adopted as a new examination tool for colorectal cancer screening. Evaluate the relationship among colorectal neoplasm, visceral adiposity and adipocytokines. 123 patients who underwent both colonoscopy and CTC were enrolled in this study. We classified three patient groups: no lesion (NL; n=40), Adenomatous polyp (Polyp; n=41), early colorectal cancer (eCRC; n=21), and advanced CRC (aCRC; n=21) groups. Total adipose area (TAA), TAA index in both polyp and CRC groups were significantly higher than that in the NL. CT colonography could not be an only useful examination to diagnose colorectal neoplasms, but also to evaluated the visceral obesity, risk factor of polyp, at the same time.
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Research Products
(8 results)
