2013 Fiscal Year Final Research Report
99mTc-MIBI SPECT and multidrug resistance-related protein in patients with ovarian cancer
| Project/Area Number |
23591806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kurume University |
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Principal Investigator |
KURATA Seiji 久留米大学, 医学部, 講師 (80268888)
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| Co-Investigator(Kenkyū-buntansha) |
KAIDA Hayato 久留米大学, 医学部, 助教 (40299425)
ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256)
USHIJIMA Kimio 久留米大学, 医学部, 准教授 (20185002)
KAMURA Toshiharu 久留米大学, 医学部, 教授 (30152870)
HAYABUCHI Naofumi 久留米大学, 医学部, 教授 (20108731)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 卵巣癌 / 核医学 / 薬剤耐性 |
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| Research Abstract |
The aim of this study was to evaluate the useful of 99mTc-MIBI SPECT for functional imaging of MDR-related protein: Thirteen women with a clinical suspicion of ovarian cancer were prospective studied. After intravenous injection of 740MBq 99mTc-MIBI, SPECT imaging at 10 minutes and 2 hours was performed. On the SPECT images, tumor uptake ratio of both early and delayed images, and washout rate of 99mTc-MIBI were calculated. The expression of MDR protein was assessed in surgically excised tumors. The immunohistochemical staining was performed. Six primary ovarian cancers were proven by histopathological examination. Five of the six ovarian cancers were positive on both early and delayed images with 99mTc-MIBI SPECT. The expression of MDR-related protein was found in all tumors. The washout rate of 99mTc-MIBI showed a significant positive correlation with YB-1 expression. Early tumor uptake ratio showed a significant positive correlation with Bax expression.
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[Journal Article] Prognostic Significance of Total Lesion Glycolysis in Patients with Advanced Non-Small Cell Lung Cancer Receiving Chemotherapy2012
Author(s)
Zaizen Y, Azuma K, Kurata S, Sadashima E, Hattori S, Sasada T , Imamura Y, Kaida H, Kawahara A, Kinoshita T, Ishibashi M and Hoshino T
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Journal Title
Eur J Radiol
Volume: 81
Pages: 4179-84
Peer Reviewed
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[Journal Article] The relationship between GLUT-1 and vascular endothelial growth factor expression and 18F-FDG uptake in esophageal squamous cell cancer patients2012
Author(s)
Kobayashi M, Kaida H, Kawahara A, Hattori S, Kurata S, Hayakawa M, Hirose Y, Uchida M, Kage M, Fujita H, Hayabuchi N, Ishibashi M
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Journal Title
Clin Nucl Med
Volume: 37
Pages: 447-52
Peer Reviewed
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