2013 Fiscal Year Final Research Report
Analysis of cellular radiation-sensitivity by phosphoproteomics
| Project/Area Number |
23591834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ENOMOTO ATSUSHI 東京大学, 医学(系)研究科(研究院), 助教 (20323602)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リン酸化プロテオーム / STK38 / 放射線感受性 |
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| Research Abstract |
STK38 (Serine/threonine kinase 38), also known as NDR1 (nuclear Dbf2-related 1), is a serine/threonine protein kinase belonging to a subclass of the protein kinase A (PKA)/PKG/PKC-like (AGC) family. I have recently reported that STK38 is activated by oxidative stresses such as X-irradiation or H2O2, and that knockdown of STK38 enhanced cellular sensitivity to DNA damage. To further clarify a role of STK38 in DNA damage response, I tried to identify a substrate of STK38 using phosoproteome analysis. I have identified not less than 30 in vitro substrates, some of which are known to be implicated in DNA damage response such as DNA repair, cell cycle checkpoint arrest, and apoptosis. I have investigated the significance of the STK38-mediated phosphorylation of their substrates
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Journal Title
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Author(s)
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Journal Title
Oncotarget
Volume: 4
Pages: 2439-2449
Peer Reviewed
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